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Updated: Jan 28, 2026

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Published on: September 3, 2016

がん細胞増殖に対する強力な武器としての複素環骨格

Himani¹, Charanjit Kaur¹, Naresh Kumar²

¹School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Current topics in medicinal chemistry

|January 27, 2026

Abstract:

Heterocyclic compounds constitute a diverse and indispensable class of molecules, particularly in the pharmaceutical area, which represent a rich source of potential anticancer agents. Their distinctive structural features enable a wide range of biological activities, making them crucial for drug development. Heterocyclic compounds containing pyrrole, furan, thiophene, oxadiazole, coumarin, or benzimidazole rings have demonstrated activity against various cancer cell lines. In this study, we have reviewed and summarised various types of heterocyclic moieties for their anticancer activity. Heterocyclic compounds can interact with DNA, inhibiting its replication and transcription, ultimately leading to cell death. Currently, several drugs, including doxorubicin, 5- fluorouracil, and methotrexate, are active against various types of cancer. In this regard, research is being conducted to enhance their therapeutic effects and minimize their side effects. For a future perspective, there remains a need to explore newer anticancer agents, with heterocyclic compounds continuing to be a center of attention. Heterocyclic compounds can interfere with signaling pathways involved in cell proliferation, differentiation, and apoptosis, thereby disrupting the cancer phenotype and serving as a key structural feature of many anticancer drugs currently available on the market.

キーワード:

抗がん剤抗腫瘍剤増殖抑制剤抗腫瘍剤アポトーシス複素環化合物

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Evaluating the Effect of SASP Factors on the Proliferation of Cancer Cells Using a Comparative Analysis of Three Distinct Methodologies

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Basicity of Heterocyclic Aromatic Amines

Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).

Cells Coordinate Growth and Proliferation

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...

Nomenclature of Aryl and Heterocyclic Amines

Nomenclature of Aryl and Heterocyclic Amines

The simplest aromatic amine is phenylamine, which contains an –NH2 functionality directly attached to an aromatic ring. The name aniline is designated for this skeleton. As shown in Figure 1, the common names of the functionalized anilines involve prefixes ortho-, meta-, and para- to indicate the substitution position. Different functionalized aniline derivatives also have notable trivial names.

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Power

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The concept of work involves force and displacement; meanwhile, the work-energy theorem relates the net work done on a body to the difference in its kinetic energy, calculated between two points on its trajectory. While none of these quantities or relations involves time explicitly, we know that the time available to accomplish work is often just as important as the amount of work itself. For example, sprinters in a race may have achieved the same velocity at the finish, therefore,...

Five-Membered Heterocyclic Aromatic Compounds: Overview

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Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom,...