LNG-IUS（レボノルゲストレル放出子宮内システム）長期挿入中に発生した子宮平滑筋肉腫の1例

Yoko Suzuki¹, Kenji Kuroda¹, Hiroko Nakagami¹

¹Department of Obstetrics and Gynecology, Yaizu City Hospital, Do-Bara 1000, Yaizu City, Shizuoka Japan.

|January 27, 2026

Abstract:

We present a case highlighting the importance of monitoring patients with leiomyoma degeneration undergoing long-term local hormonal therapy using a levonorgestrel-releasing intrauterine system (LNG-IUS). Retrospective ultrasonographic observations over 7 years revealed sequential changes in a mass at the exact location, allowing early detection of malignancy. Histological examination confirmed that malignant leiomyosarcoma cells have replaced benign smooth muscle cells. This finding underscores the need for advised monitoring of LNG-IUS users, particularly in patients with leiomyoma degeneration changes. Further research is warranted to investigate the potential association between prolonged use of LNG-IUS and the development of leiomyosarcoma. To our knowledge, this is the first reported case of leiomyosarcoma arising during the insertion of an LNG-IUS.

キーワード:

子宮内デバイス LNG-IUS 子宮筋腫子宮筋腫変性子宮平滑筋肉腫

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