ストレス管理のための個別化ランダム化試験と標準治療との比較

Ashley M Goodwin^1,2, Thevaa Chandereng¹, Heejoon Ahn^1,2

¹Northwell Health, New Hyde Park, NY 11042, USA.

Journal of personalized medicine

|January 27, 2026

まとめ

個別化N-of-1試験はストレス管理に可能性を示すが、結果は様々であった。個別化レポートに従った参加者はより大きなストレス軽減を経験し、試験デザインと報告の改善の必要性を強調した。

科学分野:

心理学
行動科学
臨床試験

背景:

心理的ストレスは、普遍的な治療選択肢が限られている一般的な問題である。
個別化（N-of-1）試験は、介入に対する個々の反応を評価する方法を提供する。
以前の研究では、標準治療と比較してストレス軽減におけるN-of-1デザインの優位性は確立されていない。

主な方法:

個別化N-of-1（N=106）群と標準治療（N=106）群を比較するランダム化比較試験。
参加者は12週間にわたり3つのストレス管理介入に従事し、生態学的瞬間評価（EMA）を通じてストレスを監視した。
N-of-1参加者は個別化レポートを受け取り、すべての参加者はフォローアップ期間のために1つの介入を選択した。

結論:

個別化（N-of-1）試験は、個々のストレス管理戦略を特定するための有望性を持っている。
個別化された推奨事項への参加者の遵守は、N-of-1試験の利点を最大化するために不可欠である。
より良い参加者の成果のためにN-of-1試験の実施と報告を最適化するためには、さらなる研究が必要である。

キーワード:

N-of-1 マインドフルネス個別化試験身体活動ストレス管理法ヨガ

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