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Updated: Jan 29, 2026

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自己早産児に生まれた成人における自己申告による疼痛感受性:早産児対正常分娩児の対照群コホート研究
Julie Vestavik Berge1, Silje Nesthus1, Merete Røineland Benestad2
1Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.
Early human development
|January 27, 2026
まとめ
自己早産児(EP)に生まれた若年成人は、早産児でない同年代と比較して27歳時点で疼痛感受性または薬剤使用に差が見られなかった。新生児期の疼痛処置は、EP群の後の疼痛感受性に影響を与えなかった。
科学分野:
- 新生児ケアのアウトカム
- 発達小児科学
- 疼痛医学
背景:
- 極早産(EP)で生まれた個人は、疼痛感受性の変化を経験する可能性がある。
- EPの個人における新生児期の疼痛曝露の長期的な影響については、さらなる調査が必要である。
研究 の 目的:
- EP生まれの成人および正常分娩児対照群における自己申告による疼痛感受性および疼痛鎮痛薬の使用を比較すること。
- EP群における新生児期の疼痛処置と成人期の疼痛感受性との関連を評価すること。
主な方法:
- 3回目の追跡調査を27歳時に行った母集団ベースのコホート研究。
- 参加者は、極早産(在胎週数≤28週)で生まれた個人およびマッチさせた正常分娩児対照群を含んだ。
- 疼痛感受性は疼痛感受性質問票(PSQ)を用いて評価し、鎮痛薬の使用および新生児期の処置も記録した。
主要な成果:
- EP生まれの成人および正常分娩児対照群の間で、PSQスコア(合計、中等度、軽度)に有意差は認められなかった。
- 両群間で疼痛鎮痛薬の使用率は同様であった。
- 新生児期の疼痛処置の回数と27歳時点での疼痛感受性との間に関連は見られなかった。
結論:
- EPで生まれた成人および正常分娩児の同年代と比較して、27歳時点での自己申告による疼痛感受性および疼痛鎮痛薬の使用は同等であった。
- 新生児期の疼痛曝露は、このコホートにおける長期的な疼痛感受性に影響を与えないようである。
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