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電気的嵐（ES）の急性期治療におけるデクスメデトミジンの評価（SEDATE）：根拠とデザイン

Pouya Motazedian¹, Pietro Di Santo¹, Graeme Prosperi-Porta²

¹Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; CAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

American heart journal

|January 27, 2026

要旨

Background:

Electrical storm (ES) is a clinical syndrome characterized by densely clustered ventricular arrhythmias, associated with substantial morbidity and mortality. Autonomic dysfunction is thought to play key role in the pathophysiology of ES, with sympathetic blockade considered a therapeutic target. However, robust data supporting this treatment strategy remains limited. The objective of the SEDATE trial is to evaluate the effectiveness and safety of dexmedetomidine in the acute management of ES.

Methods And Design:

SEDATE is a multi-center, double-blinded, randomized trial comparing dexmedetomidine to placebo in the acute treatment of patients with ES. A total of 192 participants admitted to an intensive care unit with ES will be randomized in a 1:1 fashion to receive either dexmedetomidine or placebo. Participants will undergo a study drug titration phase, followed by a 48-hour maintenance period and a subsequent study drug weaning phase. The primary outcome is a composite of all-cause in-hospital mortality and/or recurrent ventricular arrhythmia prompting intervention. All participants will be followed for the duration of their hospitalization.

Implication:

The SEDATE clinical trial aims to determine whether early use of dexmedetomidine improves in-hospital outcomes in patients with ES.

Trial Registration:

clinicaltrials.gov NCT06281977.

キーワード:

デクスメデトミジン電気的嵐鎮静心室細動心室頻拍

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