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腎石灰沈着症:旧石器時代の視点と予防のための生理学的アプローチ
Calyani Ganesan1, Lynda Frassetto2, Alan C Pao1,3,4
1Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA;
Annual review of medicine
|January 27, 2026
まとめ
現代人の食事は、ナトリウムと酸前駆物質が多く、旧石器時代の食事と比較して腎石灰沈着症(腎臓結石)のリスクを大幅に高めます。古代の食生活パターンを採用することで、結石のリスクを減らすことができるかもしれません。
科学分野:
- 進化医学
- 腎臓病学
- 栄養科学
背景:
- 腎石灰沈着症(腎臓結石)は、複雑な病因を持つ一般的な状態です。
- ヒトの食事は、特に過去10,000年間で、進化の歴史を通じて劇的な変化を遂げてきました。
研究 の 目的:
- 腎石灰沈着症のリスクに対する旧石器時代の食事の影響を探ること。
- 農業と工業の食料生産革命が腎臓結石の形成に及ぼす影響を調査すること。
主な方法:
- 進化論的および歴史的な食事の証拠のレビュー。
- 高カリウム、低ナトリウム、アルカリ豊富な旧石器時代の食事から現代の食事への移行の分析。
主要な成果:
- 旧石器時代の食事は、カリウムが多く、ナトリウムが少なく、アルカリ前駆物質が多いことが特徴でした。
- 農業と工業化の影響を受けた現代の食事は、ナトリウムと酸前駆物質が多く、結石のリスクを高めます。
- 急激な食事の変化は腎臓の恒常性に挑戦し、結石形成のリスクを高めました。
結論:
- 旧石器時代のような食事パターンへの回帰は、腎臓結石のリスクを軽減する可能性があります。
- サイアザイド、アルカリ、エンパグリフロジンなどの薬剤は可能性を示していますが、結石再発予防における有効性を確認するにはさらなる臨床試験が必要です。
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