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Updated: Jan 29, 2026

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
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大腸がんオルガノイドを進歩させるための統合ロードマップ

Youqing Zhu1, Ke He1, Zhi Shi1

  • 1Cancer Minimally Invasive Therapies Centre, Guangdong Second Provincial General Hospital, Department of Cell Biology & Institute of Biomedicine, Guangdong Provincial Biotechnology & Engineering Technology Research Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Genomic Medicine Engineering Research Center of Ministry of Education, MOE Key Laboratory of Tumor Molecular Biology, National Engineering Research Center of Genetic Medicine, State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Biomedicines
|January 28, 2026
PubMed
まとめ

患者由来の大腸がん（CRC）オルガノイドは、がん研究のための高度なモデルを提供する。将来の研究には、個別化治療と臨床的翻訳のための次世代プラットフォームと計算ツールが必要である。

キーワード:
CRCオルガノイド薬剤スクリーニングミニコロンマルチオミクスオルガノイド免疫共培養個別化治療

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Integration by Parts: Indefinite Integrals

Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
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Integration by Parts: Definite Integrals01:23

Integration by Parts: Definite Integrals

Definite integrals involving the product of two functions over a fixed interval can be evaluated using integration by parts. This method rewrites the integral as the difference of a product evaluated at the endpoints and a remaining definite integral that is often simpler to compute.A representative example is the definite integral of the inverse tangent function. Since there is no direct integration formula for arctan ⁡x, the integrand is rewritten as a product of arctan⁡ x and the...
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Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
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Op-amp circuits have significant applications in various fields, including automotive engineering. One such application is cruise control systems in cars, where op-amp circuits are integral for maintaining a constant speed. In these systems, op-amps function as both integrators and differentiators.
An integrator within an op-amp circuit produces an output directly proportional to the integral of the input signal. This is achieved by replacing the feedback resistor in a typical inverting...
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Consider a real-valued function defined on a closed interval. One of the fundamental objectives in calculus is to determine the area under the graph of such a function. When an exact computation is not readily available, this area can be estimated by dividing the interval into a finite number of equal subintervals. Each subinterval corresponds to a rectangle whose width is the length of the subinterval and whose height is determined by the value of the function at a selected point within that...
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