リアルワールドデータとエビデンス:プレシジョン・オンコロジーの最前線を切り拓く
Jingxin Jiang1,2,3, Weiwei Pan1,2,3, Liyang Sun4
1Department of Breast Surgery (Surgical Oncology), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Journal of Zhejiang University. Science. B
|January 28, 2026
まとめ
リアルワールドスタディ(RWS)は、臨床試験を超えた貴重ながん分野の洞察を提供する。多様なデータソースを分析することで、治療成績を向上させ、個別化がん治療を改善する。
科学分野:
- 腫瘍学
- リアルワールドエビデンス
- プレシジョン・メディシン
背景:
- リアルワールドスタディ(RWS)は、がん分野でますます重要になっている。
- 日常的な臨床診療からのデータを提供することで、ランダム化比較試験(RCT)を補完する。
研究 の 目的:
- がん分野におけるRWSの実施、方法論、および影響をレビューする。
- RWSがプレシジョン・メディシンと個別化がん治療にどのように貢献するかを探る。
主な方法:
- がん分野におけるRWSの体系的な分析。
- 電子カルテ(EHR)、保険請求、患者登録簿などの多様なデータソースを活用する。
主要な成果:
- RWSは、過小評価されている集団における転帰を捉え、適応拡大を促進する。
- 実際の臨床現場における長期的な安全性と有効性を評価する。
- AIのような新興技術は、データの質やプライバシーといった課題に対処している。
結論:
- RWSはプレシジョン・オンコロジーに革命をもたらしている。
- RWSと臨床研究の統合により、リアルワールドエビデンスに基づいた、より個別化された治療アプローチが可能になる。
関連する概念動画
The Evidence for Evolution
48.0K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.0K
Uncertainty in Measurement: Accuracy and Precision
100.9K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.
100.9K
Data Reporting and Recording
5.4K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Accuracy and Precision
15.2K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. Highly accurate...
15.2K
How Data are Classified: Categorical Data
44.2K
A variable, usually notated by capital letters such as X and Y, is a characteristic or measurement that can be determined for each member of a population. Data are the actual values of variables. They may be numbers, or they may be words. Datum is a single value.
Data are classified based on whether they are measurable or not. Categorical data cannot be measured; instead, it can be divided into categories. For example, if Y denotes a person's party affiliation, some examples of Y include...
Data are classified based on whether they are measurable or not. Categorical data cannot be measured; instead, it can be divided into categories. For example, if Y denotes a person's party affiliation, some examples of Y include...
44.2K
How Data are Classified: Numerical Data
37.7K
Data that are countable or measurable in specific units are called numerical or quantitative data. Quantitative data are always numbers. Quantitative data are the result of counting or measuring the attributes of a population. Amount of money, pulse rate, weight, number of people living in a town, and number of students who opt for statistics are examples of quantitative data.
Quantitative data may be either discrete or continuous. All quantitative data that take on only specific numerical...
Quantitative data may be either discrete or continuous. All quantitative data that take on only specific numerical...
37.7K


