軽度認知障害のある高齢者の認知機能と身体組成を改善する24週間の複合運動プログラム:ランダム化比較試験
Danming Xu1, Xiaochu Wu2, Junming Dai1
1Strength and Conditioning Center, Chengdu Sport University, Chengdu, Sichuan, China.
Frontiers in aging neuroscience
|January 28, 2026
まとめ
24週間の複合運動介入は、軽度認知障害(MCI)のある高齢者の身体組成を改善した。しかし、本研究では認知機能の有意な改善は見られなかった。
科学分野:
- 老年医学と運動科学;神経学と認知健康
背景:
- 軽度認知障害(MCI)は高齢者に影響を与え、身体組成と認知機能に影響を与える。;地域ベースの介入は、加齢に伴う健康状態の管理に不可欠である。
研究 の 目的:
- 軽度認知障害(MCI)のある高齢者を対象とした24週間の地域ベースの複合運動介入(MCEI)が、身体組成と認知機能に及ぼす影響を調査すること。;骨格筋量、脂肪量、および認知テストスコアの変化を評価すること。
主な方法:
- MCIのある65〜75歳の成人64名を対象とした単一施設、並行群ランダム化比較試験(RCT)。;参加者は、MCEI(有酸素運動、筋力トレーニング、バランス訓練)または通常の活動対照群のいずれかに割り付けられた。;主要評価項目には、骨格筋量(SMM)、脂肪量指数(FMI)、ミニメンタルステート検査(MMSE)、およびモントリオール認知評価(MoCA)が含まれた。
主要な成果:
- MCEI群では、対照群と比較してSMMの有意な改善とFMIの減少が観察された。;骨格筋指数(SMI)、MMSE、MoCA、またはAnimal Fluency Test(AFT)のいずれにおいても、有意な交互作用効果は見られなかった。
結論:
- 24週間のMCEIプログラムは、MCIのある高齢者の身体組成(SMMの増加、FMIの減少)を効果的に改善した。;この介入では、スクリーニングレベルの認知測定において測定可能な改善は得られなかった。;運動と認知の相互作用を明確にするためには、より長期間の介入や認知課題を用いたさらなる研究が必要である。
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