Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.8K
Oxygen Delivering System III: Tracheostomy and T-piece01:23

Oxygen Delivering System III: Tracheostomy and T-piece

6.0K
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
6.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.9K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.9K
Tumor Progression02:07

Tumor Progression

7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Correction: Romero et al. Effect of Hypoxia in the Transcriptomic Profile of Lung Fibroblasts from Idiopathic Pulmonary Fibrosis. <i>Cells</i> 2022, <i>11</i>, 3014.

Cells·2026
Same author

Cytokine and profibrotic gene expression during tracheal stenosis development in an experimental model.

Scientific reports·2026
Same author

Evaluation and Comparison of Treatment with Polymerised Collagen or Pirfenidone as Stand-Alone Therapy on the Production of Profibrotic Factors in Tracheal Stenosis and Tracheal Anastomosis Scarring After Resection.

International journal of molecular sciences·2026
Same author

Drug-tolerant persister cells in cancer: a scoping review of definitions, models, and molecular mechanisms.

Frontiers in oncology·2026
Same author

The Role of Neutrophil, Monocyte and Macrophage Calprotectin and S100A12 in the Fibrotic Process.

Biomolecules·2026
Same author

Glyoxalase-1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine.

ChemMedChem·2025

関連する実験動画

Updated: Jan 29, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

12.4K

腫瘍微小環境：パズルにピースを追加する

Dolores Aguilar-Cazares1, Mario Perez-Medina1,2, Jesus J Benito-Lopez1

  • 1Laboratorio de Investigacion en Cancer Pulmonar, Departamento de Enfermedades Cronico-Degenerativas, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosio Villegas", Mexico City, Mexico.

Frontiers in immunology
|January 28, 2026
PubMed
まとめ

腫瘍細胞は微小環境と相互作用し、逆説的にがんの成長を促進します。これらの複雑な細胞ネットワークを理解することは、抗腫瘍免疫を高め、治療抵抗性を克服する新しい治療法を開発するための鍵となります。

キーワード:
細胞外小胞免疫チェックポイント免疫応答代謝再プログラミング抵抗間質細胞組織リモデリング腫瘍回避メカニズム

さらに関連する動画

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

12.0K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.4K

関連する実験動画

Last Updated: Jan 29, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

12.4K
Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

12.0K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.4K

科学分野:

  • 腫瘍学
  • 免疫学
  • 細胞生物学

背景:

  • 腫瘍微小環境（TME）は、直接接触または可溶性因子を介して相互作用する悪性細胞、間質細胞、免疫細胞、および内皮細胞から構成される。
  • 腫瘍の組成と免疫細胞の浸潤は進化し、動的で不均一なニッチを形成する。
  • TME内のこれらの細胞間相互作用は、免疫防御と腫瘍の進行に影響を与える。

研究 の 目的:

  • TME内の細胞間相互作用に関する知識を統合すること。
  • これらのネットワークが免疫細胞を巻き込みながら、どのように逆説的に腫瘍の進行を支持するかを理解すること。
  • 腫瘍促進性コミュニケーションネットワークを標的とする治療戦略を特定すること。

主な方法:

  • 文献レビューと知識統合。
  • 免疫細胞の関与と間質細胞を介した恒常性プロセスのアナリシス。
  • 代謝再プログラミング、酸化ストレス、細胞外小胞シグナリングの探求。

主要な成果:

  • TMEにおける細胞間相互作用は複雑かつ動的であり、腫瘍の発生に影響を与える。
  • 免疫細胞と間質成分は逆説的な役割を果たし、腫瘍の増殖を促進することもある。
  • 代謝変化、酸化ストレス、細胞外小胞は腫瘍の抵抗性に寄与する。

結論:

  • TMEの細胞間相互作用を理解するためには、包括的なフレームワークが必要である。
  • 腫瘍促進性コミュニケーションネットワークを標的とすることで、抗腫瘍免疫を高めることができる。
  • がんを制御し、抵抗性を克服するためには、多標的免疫療法の開発が不可欠である。