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Updated: Jan 30, 2026

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics
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ミトキサントロンは悪性脳腫瘍モデルにおけるCD24/Siglec-10発現を変化させる

Jan Kopecky1, Julio Enríquez Pérez1, Stevanus Jonathan1

  • 1Department of Clinical Sciences Lund, Neurosurgery, Lund University, Lund, Sweden.

Scientific reports
|January 28, 2026
PubMed
まとめ

ミトキサントロン治療は、悪性脳腫瘍細胞のCD24レベルを低下させ、免疫抑制性のSiglec-10+細胞を減少させた。このCD24/Siglec-10軸の標的化は、抗腫瘍免疫を高める可能性がある。

キーワード:
悪性脳腫瘍ミトキサントロンCD24Siglec-10免疫療法腫瘍微小環境神経腫瘍学免疫学薬理学

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