多発性硬化症患者における機能的トレーニングによる循環インドール-3-乳酸レベル低下の軽減
Tiffany Wences Chirino1, Frederike Adammek1, Sergen Belen1,2
1Sports Medicine Research Group, Institute for Sport and Sport Science, TU Dortmund University, Dortmund, Germany.
Acta physiologica (Oxford, England)
|January 28, 2026
まとめ
定期的な運動と10週間のマルチモーダルトレーニングプログラムは、多発性硬化症患者のインドール-3-乳酸/インドール-3-酢酸指数を大幅に改善した。単回の運動セッションもインドール-3-乳酸レベルを上昇させ、神経保護効果を示唆している。
科学分野:
- 神経科学
- 微生物学
- 免疫学
背景:
- インドールは、トリプトファン由来の腸内細菌叢代謝物であり、多発性硬化症(MS)における腸-脳相関に影響を与える。
- インドール-3-乳酸(ILA)はMS患者で減少し、動物モデルでは抗炎症作用、再髄鞘化作用を示す。
- ILAとインドール-3-酢酸(IAA)の比(ILA/IAA)は、運動や食事によって変化する神経保護指数として機能する。
主な方法:
- 31人のRRMS患者を対象としたランダム化比較試験の二次解析。
- ベースライン時、10週間の介入後、および一致させた健常対照群との血清インドール濃度(LC-MS/MSで測定)の比較。
- トレーニングセッションの前、中、直後の採血による急激な運動効果の評価。
結論:
- 10週間のマルチモーダル機能トレーニングプログラムは、RRMS患者のILA/IAA指数を改善し、腸内細菌叢における神経保護的なシフトを示唆した。
- 急性の運動は、循環ILAレベルを急速に増加させることができる。
- 運動介入は、MSにおける腸内細菌叢代謝物の調節と神経保護のサポートに有望である。
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