Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Relaxation of Skeletal Muscles01:29

Relaxation of Skeletal Muscles

5.8K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
5.8K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

3.1K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.1K
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

958
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
958
Structural Isomerism02:34

Structural Isomerism

21.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.7K
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

817
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
817
Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

1.3K
Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
1.3K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

In situ elucidation of the formation mechanism of donor-acceptor complexes responsible for exciplex generation.

Communications chemistry·2026
Same author

Pyrazole-Substituted 3-Hydroxychromones: Conformation-Dependent Proton-Transfer Isomerization.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

A General and Scalable Chiral Surrogate Rotaxane Strategy for Highly Enantioenriched Mechanically Planar Chiral Rotaxanes.

Angewandte Chemie (International ed. in English)·2026
Same author

Asymmetric organic NIR chromophores for bioimaging and phototherapy.

Nanoscale·2026
Same author

Tuning the Magnetic Properties of Heterotrimetallic Co-M-Co (M = Ni and Pd) Chain Complexes via Redox Modulation and Metal Ion Replacement.

Inorganic chemistry·2026
Same author

Asymmetric Diphosphane Dioxides With A-π-A-π'-D Scaffolds for High-Purity Deep-Blue Luminescence.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

関連する実験動画

Updated: Jan 31, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.8K

相互接続されたロタキサンは,TADFに特異な興奮状態の構造的緩和を可能にします.

Chuan-Jing Lin1, Kai-Hsin Chang1, Chun-Yen Lin1

  • 1Department of Chemistry, National Taiwan University, Taipei 106319, Taiwan.

Journal of the American Chemical Society
|January 29, 2026
PubMed
まとめ

私たちは,有機発光ダイオード (OLED) 用のロタキサンベースの新型熱活性化遅延光 (TADF) エクシプレックスを開発しました. この機械的に相互接続した分子は,効率的な緑色の電光発光と動作の安定性の向上を示しています.

さらに関連する動画

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.5K
15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale
08:09

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale

Published on: April 19, 2021

6.1K

関連する実験動画

Last Updated: Jan 31, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.8K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.5K
15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale
08:09

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale

Published on: April 19, 2021

6.1K

科学分野:

  • マテリアルサイエンス 材料科学
  • 有機化学 オーガニック・ケミストリー
  • 物理化学 物理化学

背景:

  • 熱的に活性化された遅延光 (TADF) 材料は,高効率の有機発光ダイオード (OLED) に不可欠です.
  • エクシプレックスは調節可能な電子特性を提供しますが,安定性の問題を抱えていることが多いです.
  • 機械的に相互接続された分子 (MIM) は,ユニークな構造制御と強化された安定性を提供します.

研究 の 目的:

  • OLEDアプリケーションのための最初のロタキサンベースのTADFエクシプレックスを実証するために.
  • ロタキサンエクシプレックスの興奮状態構造的リラックスダイナミクスを調査するために.
  • OLEDデバイスにおけるロタキサンエクシプレックスの性能を評価するために.

主な方法:

  • トリアゼンケージホストとカルバゾール誘導体のゲストを用いたロタキサンエクスシプレックス (CT-ロタキサン) の合成.
  • 遅れた光,シングレット・トリプルエナジーギャップ (ΔEST),および反転のシステム間交差率を含むTADF特性の特徴.
  • 溶液および固体状態における構造的緩和を研究するための時間解像度スペクトロスコピー.
  • ロタキサン型OLEDの製造と試験.

主要な成果:

  • 合成されたCT-ロタキサンは,マイクロ秒スケールで遅延した光とTADFの特徴を示しています.
  • 溶液 (264 ps) と固体 (177 ns) の両方の状態で顕著な構造的緩和が観察されました.
  • ロタキサン型OLEDは,緑色の電光発光で7.23%のピーク外部量子効率 (EQE) を達成した.
  • ロタキサンOLEDは,非ロタキサンOLEDよりも効率性と運用安定性において優れていた.

結論:

  • 機械的に相互接続されたTADFエクシプレックスは,先進的な光電子機器のための有望な戦略を表しています.
  • CT-Rotaxaneのユニークな構造は,OLEDのパフォーマンスを向上させます.
  • Rotaxaneアーキテクチャは,TADF素材の効率と安定性を改善するための経路を提供します.