ヒトの内在的な寿命の遺伝性は,混同要因に対処した場合,約50%です

Ben Shenhar¹, Glen Pridham¹, Thaís Lopes De Oliveira²

¹Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Science (New York, N.Y.)

|January 29, 2026

まとめ

人間の寿命の遺伝性は,これまで考えられていたよりも高い. 事故などの外部要因を補正すると,長寿に対する遺伝的影響は50%以上で,高齢化研究と公衆衛生に影響を及ぼしていることが明らかになる.

科学分野:

遺伝学遺伝学とは
デモグラフィーデモグラフィー人口統計
ゲロントロジーはゲロントロジーの学科です.

背景:

人間の寿命の遺伝可能性の推定は低いもので,双子の研究では20~25%と,血統研究では6%と推定されている.
以前の推定は,外因的な死亡率 (事故,感染症など) によって混乱させられ,長寿の真の遺伝的要素を隠している可能性があります.

研究の目的:

外的な死亡率を考慮することによって,人間の寿命の遺伝性を再評価する.
本質的な死亡率と全体的な長寿に対する遺伝的影響の範囲を決定する.

主な方法:

外的な死亡率要因を調整するために数学モデリングを使用した.
遺伝子と環境の影響を区別するために,一緒に育てられた双子のコホートを分析しました.

主要な成果:

固有の死亡率による人間の寿命に対する修正された遺伝可能性の推定値は50%以上です.
この改訂された遺伝性は,他の複雑な人間の特徴と,他の種における寿命遺伝性と一致しています.

結論:

人間の寿命はかなり遺伝的であり,遺伝的要因は内在的な死亡率に大きな役割を果たします.
この高い遺伝性を理解することで,老化メカニズムの研究を進め,公衆衛生戦略を策定し,医療介入を導くことができます.

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