抗がん剤の効力（IC50）予測のための深層学習モデルのベンチマーキングと医薬品化学者への洞察

Potency (IC₅₀) prediction of small molecules is pivotal for anticancer drug development. This study benchmarked five deep learning (DL) models for IC₅₀ prediction-DeepCDR, DrugCell, PaccMann, Precily, and tCNN-against a simple mean-based Baseline using standardized GDSC datasets and recently published anticancer compounds. To ensure practicality, conventional error metrics were supplemented with percentage error, log error, three-sigma limit, and a newly proposed Experimental Variability-Aware Prediction Accuracy statistic. The models performed well on randomly split data and unseen cell lines but showed sharply reduced accuracy for unseen compounds. Though all DL models exhibited similar performance trends, DeepCDR, DrugCell, and tCNN held a slight edge in most testing scenarios. Interestingly, several DL algorithms could not significantly outperform the Baseline model in many tests. Assessing prediction error against physicochemical and biological properties of compounds and cell lines revealed weak correlation, highlighting an underexplored aspect of model performance. A user-friendly web server (https://nlplab1.isical.ac.in/ic50.php) was also developed for IC₅₀ prediction of new compounds against cancer cell lines.