ボルリコナゾール誘発性急性間質性肺水腫および血管性浮腫の1例報告
Yuzhen Jin1, Lijie Qin1, Peng Liu1
1Department of Respiratory and Critical Care Medicine, Cangzhou Fifth Hospital (People's Hospital of Qingxian), Cangzhou, China.
BMC pulmonary medicine
|January 29, 2026
まとめ
ボルリコナゾールはまれに急性間質性肺水腫および血管性浮腫を引き起こす可能性があります。肺炎患者において、薬剤の中止とコルチコステロイドの使用により急速な回復が得られました。
科学分野:
- 医学
- 肺学
- 薬理学
背景:
- ボルリコナゾールは侵襲性感染症の主要な抗真菌薬です。
- ボルリコナゾール誘発性間質性肺水腫はまれな有害事象です。
研究 の 目的:
- ボルリコナゾール誘発性急性間質性肺水腫のまれな症例を報告すること。
- この病状の診断上の課題と管理を強調すること。
主な方法:
- 肺炎の74歳女性の症例提示。
- 胸部CT、B型ナトリウム利尿ペプチド(BNP)値、心エコー検査を含む臨床評価。
- 治療にはボルリコナゾールの休止およびコルチコステロイド療法が含まれました。
主要な成果:
- 患者は顔面浮腫、呼吸困難、肺水腫の症状を発症しました。
- 胸部CTで両側胸水および小葉間隔壁肥厚が認められました。
- ボルリコナゾールの休止およびコルチコステロイド投与後に臨床的改善が急速に認められました。
結論:
- ボルリコナゾール過敏症は、急性間質性肺水腫および血管性浮腫として現れることがあります。
- この病状は心原性肺水腫と誤認されることがあります。
- 早期診断とコルチコステロイド治療は、良好な転帰のために不可欠です。
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