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RNA Stability01:53

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Classification of Skeletal Muscle Fibers01:48

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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
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The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
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The muscles that move the head are a dynamic and complex group of structures that work together to facilitate a wide range of head movements, including rotation, flexion, extension, and lateral bending.
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The abdominal wall encircles the abdominal cavity, providing flexible protection and shielding the internal organs from harm. It is bordered at the top by the xiphoid process and costal margins, at the back by the vertebral column, and at the bottom by the pelvic bones and inguinal ligament. The abdominal wall is divided into two regions — the anterolateral and posterior regions.
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Nine muscles are involved in arm movements. Two of these, the pectoralis major and latissimus dorsi, originate from the axial skeleton and are called axial muscles. The other seven originate from the scapula and are called the scapular muscles.
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EIF4A3誘導性circRNA circSnd1はEEF1A1を安定化させることにより筋萎縮および筋老化を促進する

Jin Li1,2, Bing Jin1,2, Yuwei Yan1,2

  • 1Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Sciences, Shanghai University, Nantong, China.

Journal of cachexia, sarcopenia and muscle
|January 30, 2026
PubMed
まとめ

円形RNA circSnd1は、EEF1A1タンパク質を安定化させることにより、筋萎縮および老化を促進する。circSnd1を阻害すると筋消耗が改善され、筋萎縮の潜在的な治療標的となる可能性がある。

キーワード:
EEF1A1ユビキチン化EIF4A3FAT10circSnd1筋老化筋萎縮

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科学分野:

  • 分子生物学
  • 細胞生物学
  • 老年学

背景:

  • 筋萎縮は、老化および慢性疾患の重大な合併症である。
  • 筋萎縮に対する現在の治療法は限られている。
  • circRNAの筋萎縮における役割は、依然としてほとんど探求されていない。

研究 の 目的:

  • circSnd1の筋萎縮および老化における機能とメカニズムを調査する。
  • 筋消耗に関与するcircRNAを同定する。

主な方法:

  • 筋萎縮モデルおよび高齢の筋肉におけるcircRNAシーケンシングおよび定量的リアルタイムPCR。
  • circSnd1の役割を評価するための機能獲得および機能喪失実験。
  • 分子メカニズムを解明するためのRNA immunoprecipitation followed by mass spectrometry (RIP-MS)およびRIPアッセイ。

主要な成果:

  • circSnd1、SND1遺伝子由来の保存されたcircRNAは、筋萎縮モデルおよび高齢のヒトおよびマウスの筋肉でアップレギュレーションされる。
  • circSnd1は、細胞および動物モデルにおいて筋萎縮および老化を促進する。
  • circSnd1の発現はEIF4A3によって制御され、FAT10との相互作用を介してEEF1A1タンパク質を安定化させることにより筋萎縮を促進し、EEF1A1のユビキチン化を減少させる。

結論:

  • circSnd1は、筋萎縮および老化を促進する新規circRNAとして同定された。
  • circSnd1は、筋消耗性疾患と闘うための潜在的な治療標的を表す。