潰瘍性大腸炎治療薬であるベドリズマブ誘発性急性間質性腎炎
Darren Fernandes1, Alok Mathew1, Alastair Ferraro2
1The Department of Gastroenterology, Nottingham Digestive Diseases Centre, Derby Road, Nottingham, NG7 2UH, United Kingdom.
Oxford medical case reports
|January 30, 2026
まとめ
潰瘍性大腸炎(UC)治療薬であるベドリズマブは、まれに急性間質性腎炎を引き起こすことがあります。ベドリズマブの中止とステロイド治療により、UC患者の腎機能は回復しました。
科学分野:
- 消化器病学と腎臓病学
- 免疫学と薬理学
背景:
- ベドリズマブは、潰瘍性大腸炎(UC)に対して確立された安全性プロファイルを持つ、腸管選択的な抗インテグリンモノクローナル抗体である。
- ベドリズマブ治療に伴うまれな合併症は、消化器専門医による注意深いモニタリングと認識を必要とする。
研究 の 目的:
- UC患者におけるベドリズマブ治療に関連した急性間質性腎炎(AIN)のまれな症例を報告する。
- ベドリズマブ投与患者における腎合併症の認識の重要性を強調する。
主な方法:
- UCおよび肝硬変患者の53歳男性症例の詳細な臨床経過、診断検査、治療。
- 腎生検結果や治療反応性などの診断所見を含む。
主要な成果:
- UC治療中に腎機能が悪化し、反応性の尿沈渣が認められた。
- 腎生検により急性間質性腎炎と診断された。
- ベドリズマブの中止と高用量ステロイドの開始により、腎機能は著しく回復した。
結論:
- 急性間質性腎炎は、UC患者におけるベドリズマブ治療に関連する可能性のある、まれな有害事象である。
- 薬剤の中止やコルチコステロイド治療を含む、迅速な認識と管理は、良好な腎転帰につながる可能性がある。
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