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Updated: Jan 31, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

両眼結膜下非特異的末梢T細胞リンパ腫の化学療法による治療成功例：症例報告

Haruka Ota¹, Koji Arihiro², Keichiro Mihara³

¹Ophthalmology, Kure Saiseikai Hospital, Hiroshima, JPN.

|January 30, 2026

Abstract:

Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) typically presents in lymph nodes with advanced-stage disease. Ocular adnexal involvement, particularly bilateral subconjunctival presentation, is exceptionally rare. We describe a 39-year-old woman who presented with progressive bilateral conjunctival masses despite one year of topical corticosteroid treatment. Examination revealed well-demarcated pink subconjunctival nodules in both eyes. Following surgical excision, histopathological and immunophenotypic analyses confirmed PTCL-NOS with CD3+/CD4+ T-cell infiltration. Molecular studies detected clonal T-cell receptor gene rearrangement in both tumor tissue and bone marrow, indicating stage II disease. The patient achieved complete remission with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy and remains disease-free after three years. To our knowledge, this represents the first reported case of primary bilateral subconjunctival PTCL-NOS successfully managed with systemic chemotherapy, highlighting the importance of comprehensive evaluation and aggressive treatment in this unusual presentation.

キーワード:

両側性 chop 結膜リンパ腫 ptcl-nos

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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

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Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

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