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Updated: Jan 31, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

骨髄異形成症候群を伴う急性骨髄性白血病：二重同一性または活動性形質転換の症例

Benjamin J Lee^1,2, Shawn P Griffin^1,2, Deepa Jeyakumar³

¹Department of Pharmacy Chao Family Comprehensive Cancer Center University of California Irvine Health Orange California USA.

|January 30, 2026

要旨

Introduction:

Acute myeloid leukemia (AML) with plasmacytoid dendritic cell differentiation (pDC-AML) is a newly described subtype of leukemia with features resembling blastic plasmacytoid dendritic cell neoplasm (BPDCN).

Case Presentation:

Herein, we present a case of pDC-AML in which bone marrow findings were best classified as AML, whereas cutaneous manifestations by morphology and immunophenotype were highly suggestive of a pDC neoplasm.

Results:

A high-dose cytarabine with anthracycline backbone and venetoclax was administered based on efficacy in AML and BPDCN, respectively. The patient achieved complete remission as well as resolution of FDG-avid activity by PET-CT imaging.

Conclusions:

This report highlights that clinical correlation with immunophenotype and molecular testing is important in distinguishing these unique entities to guide appropriate diagnosis and management.

キーワード:

急性骨髄性白血病芽球性形質細胞様樹状細胞腫瘍 pDC-AML 形質細胞様樹状細胞

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Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

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