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Updated: Jan 31, 2026

Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats

Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats

Published on: September 17, 2014

虚血性脳卒中後の二次予防と血管リスク管理に対する3年間のアドヒアランス

Erlend Fagerli¹, Hanne Ellekjær^2,3, Olav Spigset^4,5

¹Department of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

European stroke journal

|January 30, 2026

要旨

Introduction:

Long-term adherence to secondary prevention after ischemic stroke remains unclear. This study aimed to evaluate medication adherence, attainment of vascular treatment targets, and clinical characteristics that influence target achievement 3 years post-stroke.

Patients And Methods:

We included 665 home-dwelling ischemic stroke patients from the Norwegian Cognitive Impairment After Stroke study, admitted between May 2015 and March 2017 (n = 431 were followed for 3 years). Medication adherence was assessed using the 4-item Morisky Medication Adherence Scale, medication persistence, and guideline-based treatment targets: blood pressure (BP) < 140/90 mmHg, LDL cholesterol (LDL-C) < 2.0 mmol/L, and hemoglobin A1c (HbA1c) ⩽ 53 mmol/mol.

Results:

At discharge, prescription rates were 97% for antithrombotics, 67% for antihypertensives, 88% for lipid-lowering drugs (LLD), and 10% for antidiabetics. Three years later, persistence rates were 97%, 91%, 83%, and 94%, respectively, with 73% reporting high medication adherence. Target achievement rates were 42% for BP, 47% for LDL-C, and 75% for HbA1c among diabetic patients. Younger age was associated with better BP control (OR 0.974 per year, 95% CI 0.957-0.992). Women had poorer LDL-C control (OR 0.55, 95% CI 0.33-0.91). More LLD (OR 1.25, 95% CI 1.14-1.37) and higher comorbidity (OR 1.26, 95% CI 1.10-1.44) were associated with improved LDL-C control.

Conclusion:

Control of risk factors remained unsatisfactory 3 years after ischemic stroke, despite relatively high persistence and adherence rates. Improved focus on implementing optimal secondary prevention for Norwegian stroke patients is necessary.

キーワード:

二次予防血圧虚血性脳卒中服薬アドヒアランス脳卒中血管リスク因子

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