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Updated: Jan 31, 2026

Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets

Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets

Published on: July 7, 2010

イチゴ灰色かび病に対するイプフルフェノキンの有効性：AlphaFoldベースの構造モデリングとゲノムワイドトランスクリプトーム解析からの洞察

Sungyu Choi¹, Doeun Son¹, Hyeong-Rok Jang¹

¹Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.

Journal of agricultural and food chemistry

|January 30, 2026

Abstract:

Gray mold caused by Botrytis cinerea significantly threatens strawberry production. This study evaluated the efficacy of ipflufenoquin, a novel dihydroorotate dehydrogenase (DHODH) inhibitor, against fungal pathogens isolated from Korean strawberry fields in 2023. Ipflufenoquin demonstrated a high in vitro sensitivity to B. cinerea and broad activity against other pathogens. Fruit and greenhouse trials confirmed its robust control of gray mold, including strains resistant to multiple fungicide classes. However, treatment shifted the fungal community, promoting less sensitive genera, such as Cladosporium and Rhizopus. Structural modeling with AlphaFold2 and molecular docking confirmed that ipflufenoquin binds to the quinone binding tunnel of DHODH, correlating binding affinity with susceptibility. Additionally, RNA-seq analysis revealed that ipflufenoquin suppresses primary metabolic pathways while triggering a robust stress response, up-regulating detoxification and efflux transporter genes. This integrated study confirms the efficacy of ipflufenoquin against gray mold and elucidates its molecular impacts, offering essential data for sustainable management strategies.

キーワード:

DHODH阻害剤 RNA-seq alphafold2 灰色かび病イプフルフェノキン分子ドッキングイチゴ

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A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

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