リボヌクレオチド還元酵素βサブユニットにおける構造ゲート制御型マルチサイトプロトン共役電子移動
Jiahua Deng1, Sharon Hammes-Schiffer1
1Department of Chemistry, Princeton University, Princeton, NJ 08544.
まとめ
本研究は、DNA合成に不可欠なリボヌクレオチド還元酵素(RNR)における主要残基間のプロトン共役電子移動(PCET)の発生メカニズムを明らかにする。このメカニズムの理解は、タンパク質工学や治療法の開発に役立つ。
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