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Updated: Feb 1, 2026

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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近接標識に基づく細胞内プロテオームマッピングの最近の進歩

Gang Wang1, Jiapeng Liu2, Xuege Sun3

  • 1College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.

Molecular & cellular proteomics : MCP
|January 30, 2026
PubMed

キーワード:
近接標識プロテオーム細胞内マッピングタンパク質局在ポスト翻訳修飾

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The homogenate obtained after cell lysis contains various membrane-bound organelles that can be further separated into pure fractions by subcellular fractionation. These isolates are used to study specific cellular components, analyze localized protein activity, and are even employed in diagnostics. Fractionation is typically achieved using centrifugation methods, the most common being density-gradient and differential centrifugation.
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Proteomics

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
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