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Updated: Feb 1, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

慢性リンパ性白血病における壊死性筋膜炎：診断上の課題、管理、および学習ポイント

Arthur Chen Wun Tan¹, Eun Young Han², Ezanul Harriz Abd Wahab³

¹Orthopaedic Surgery, University Hospitals Sussex NHS Foundation Trust, Brighton, England, UK arthurchenwun.tan1@nhs.net.

BMJ case reports

|January 30, 2026

Abstract:

Necrotising soft tissue infection (NSTI), or necrotising fasciitis (NF), is a life-threatening, rapidly spreading bacterial infection affecting soft tissues. Mortality rates can be up to 70%, emphasising the need for early diagnosis and intervention. However, timely identification remains challenging, particularly in immunocompromised patients, due to nonspecific early signs. This case involves a patient who developed NF 12 days after R-CHOP (Rituximab, Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisolone) chemotherapy. Despite clinical and radiological evidence of NF and a high Laboratory Risk Indicator for Necrotising Fasciitis score, blood tests revealed leucopenia, neutropenia and lymphopenia, with no fever and a low National Early Warning Score of one. This atypical presentation underscores the difficulty in diagnosing NF in immunosuppressed individuals. The case highlights the complexity of managing NSTI in such populations, stressing the importance of rapid recognition and treatment to improve outcomes in these high-risk scenarios.

キーワード:

化学療法血液学（血液製剤投与を含む）感染症整形外科および外傷外科形成外科および再建外科

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