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Updated: Feb 1, 2026

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

カルダモンがカフェテリア食を与えられたマウスの神経炎症、学習および記憶に及ぼす影響

Anfal Al-Dalaeen¹, Nour Batarseh¹, Sally Atawneh²

¹Department of Clinical Nutrition and Dietetics, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan.

Endocrinology, diabetes & metabolism

|January 31, 2026

要旨

Background:

The consumption of a cafeteria diet is described as deleterious to cognitive performance, potentially due to inducing inflammation in the brain. Cardamom, a potent antioxidant, may benefit brain health. In the current study, we assessed the effects of a cafeteria diet on neuroinflammation and its reversal by dietary cardamom.

Methods:

Thirty-six male C57BL/6 mice were fed with a cafeteria diet (CAF) to induce obesity for ten weeks. They were then divided into four treatment groups: standard diet (SD), cafeteria diet (CAF), cafeteria diet with cardamom (CAF-CARD) and standard diet with cardamom (SD-CARD). After administering cardamom orally (500 mg/kg/day) for 4 weeks, the mice were subjected at week 14 to behavioural tests assessing learning and memory, and hippocampal tumour necrosis factor (TNF-α) levels were measured to evaluate neuroinflammation.

Results:

The TNF-alpha level in the CAF group was higher than in the SD group (p < 0.001), and significantly lower in the CAF-CARD group compared to the CAF group (p < 0.01). The recognition index (RI) was significantly lower in the CAF group, while cardamom supplementation improved the RI compared to the CAF group (p < 0.01). There was a significant difference in spatial memory between SD and CAF groups (p < 0.01). In terms of digging behaviour, which indicates anxiety, mice in the CAF group buried 58% of the marbles compared to 38% in the SD group (p < 0.01). However, this behaviour decreased in the CAF-CARD group compared to the CAF group (p < 0.001).

Conclusion:

Cardamom appears to be beneficial for obesity-related cognitive impairments and dysfunction in the hippocampus.

キーワード:

脳機能カルダモン記憶神経炎症肥満

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