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Updated: Feb 2, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

成人ラットにおける慢性アルコール曝露の不安および疼痛関連行動に対するパラメトリック効果

Maria E Secci¹, Loren Johnson¹, Thomas Lobell¹

¹Department of Physiology.

Alcohol (Fayetteville, N.Y.)

|January 31, 2026

Abstract:

Many animal models of alcohol dependence utilize forced alcohol exposure, including chronic intermittent exposure to alcohol vapor, to induce high blood alcohol concentrations (BACs) and withdrawal-associated behaviors similar to those seen in clinical contexts. Chronic alcohol exposure and withdrawal are especially important in influencing the expression of negative symptoms (e.g., negative affect and pain), which, in turn, increase alcohol consumption. However, cessation of chronic alcohol vapor exposure does not always lead to those "canonical" withdrawal behaviors in rodents. Environmental and genetic factors may modulate alcohol effects on behavior during withdrawal. Here, we used retrospective data analysis to determine associations between alcohol vapor exposure parameters (e.g., BACs, duration of exposure) and anxiety- or pain-like behavior in adult male and female Wistar rats. Our results indicate that specific vapor exposure parameters are predictive of thermal hyperalgesia in Wistar rats but less so for anxiety-like behavior during alcohol withdrawal; collectively, these data may be helpful in informing experiments designed to investigate chronic alcohol effects on behavioral outcomes.

キーワード:

アルコール不安依存痛覚ラット蒸気曝露離脱

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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Published on: August 30, 2022

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