米国人女性におけるペルフルオロアルキル物質およびポリフルオロアルキル物質への曝露と生殖寿命との関連:集団ベースの研究
Anhui Ning1, Feng Shao2, Qingzheng Yang3
1Department of Epidemiology, Institute for Applied Research in Public Health, School of Public Health, Nantong University, Nantong, 226019, China.
Abstract:
Wide exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) poses a great risk to human reproductive health. Reproductive longevity is a major factor influencing the female reproductive cycle and affects women's healthy ageing. However, few studies have comprehensively evaluated the correlation between serum PFAS concentrations and female reproductive age, including menarche, reproductive longevity, and menopause. The purpose of this research is to investigate the correlation between serum PFAS levels and female reproductive age using linear regression models based on the National Health and Nutrition Examination Survey (NHANES) database. A total of 4,743 participants were included in this analysis, and the results showed that age at menopause was inversely associated with perfluorooctanoic acid (PFOA) (β = -0.77, 95% CI = -1.36, -0.18, P = 0.01), perfluorohexane sulfonic acid (PFHxS) (β = -1.07, 95% CI = -1.53, -0.60, P < 0.001) and perfluorooctane sulfonic acid (PFOS) (β = -0.84, 95% CI = -1.30, -0.38, P < 0.001). Moreover, the results showed that PFOS (β = -0.89, 95% CI = -1.36, -0.42, P < 0.001), PFHxS (β = -1.08, 95% CI = -1.55, -0.60, P < 0.001), and PFOA (β = -0.68, 95% CI = -1.28, -0.08, P = 0.03) exposure were inversely related to reproductive longevity in women, exhibiting a strong dose-response trend. Evidence from the study indicates that exposure to PFAS may raise the risk of shortened reproductive longevity in women.
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