Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

3.0K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
3.0K
Coordination Number and Geometry02:57

Coordination Number and Geometry

19.0K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
19.0K
Coordination Compounds and Nomenclature02:54

Coordination Compounds and Nomenclature

26.7K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
26.7K
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

11.6K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
11.6K
GTPases and their Regulation02:14

GTPases and their Regulation

9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.8K
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

603
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
603

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy.

Science translational medicine·2026
Same author

Entorhinal Cholecystokinin in Alzheimer's Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model.

Cellular and molecular neurobiology·2026
Same author

Role of Neuronal Cholecystokinin Receptor: An Emerging Therapeutic Target for Ameliorating Neurological Diseases.

Molecular neurobiology·2025
Same author

Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation.

Nature communications·2025
Same author

Cholecystokinin modulates age-dependent thalamocortical neuroplasticity.

eLife·2025
Same author

Upregulation of CCK3R leading to the suppression of chronic seizures.

Translational psychiatry·2025

関連する実験動画

Updated: Feb 2, 2026

Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

8.0K

海馬台状皮質経路とCA3-シャファー側枝求情報は空間学習を協調的に制御する

Fengwen Huang1,2, Stephen Temitayo Bello3,4, Siu Hin Lau3

  • 1Department of Neuroscience, City University of Hong Kong, Hong Kong, Kowloon Tong, China. fwhuang2@standford.edu.

Communications biology
|January 31, 2026
PubMed
まとめ

内側嗅内皮質からの入力は、空間学習と記憶に不可欠である。本研究は、これらの入力が海馬回路をどのように調節し、空間コーディングと神経可塑性に影響を与えるかを明らかにする。

キーワード:
海馬台状皮質経路CA3-シャファー側枝求情報空間学習内側嗅内皮質海馬回路神経可塑性

さらに関連する動画

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
08:16

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

2.7K
Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties
12:55

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

9.1K

関連する実験動画

Last Updated: Feb 2, 2026

Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

8.0K
Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
08:16

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

2.7K
Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties
12:55

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

9.1K

科学分野:

  • 神経科学
  • システム神経科学
  • 認知神経科学

背景:

  • 嗅内皮質-海馬系は、空間学習と記憶に不可欠である。
  • この系における空間コーディングの神経学的相互作用は、完全には理解されていない。

研究 の 目的:

  • 空間コーディングのための海馬計算を嗅内皮質入力がどのように調節するかを調査する。
  • 空間学習と記憶における内側嗅内皮質入力の役割を解明する。

主な方法:

  • 統合的な多角的アプローチ：in vivoカルシウムイメージング、オプトジェネティクス、ケモジェネティクス、電気生理学、免疫組織化学、およびモリス水迷路。
  • 特定の神経経路の共活性化のために、二重光シータバースト刺激を利用した。

主要な成果:

  • 空間学習初期において、CA3神経細胞のCA1投射は過活動を示し、課題遂行に伴い低下した。
  • 内側嗅内皮質-海馬求情報の不活性化は、空間学習とCA3神経活動を損なった。
  • CA3-CA1およびMEC-CA1経路の共活性化は、背側CA1における堅牢なヘテロシナプス長期増強を誘発した。

結論:

  • 嗅内皮質-海馬求情報は、海馬機能に対して多層的な調節制御を行う。
  • 内側嗅内皮質からの入力は、正確な空間課題遂行に不可欠である。
  • 本研究結果は、記憶関連神経疾患の理解を深める。