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Updated: Feb 2, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

イブプロフェンマイクロエマルゲル製剤の設計と最適化：経皮薬物送達の効果的かつ強化された送達を目指して

Amna Nosheen Jaweria¹, Sehar Khalid¹, Maiza Mubashaar¹

¹Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Pakistan journal of pharmaceutical sciences

|February 1, 2026

要旨

Background:

The oral administration of ibuprofen is limited due to gastrointestinal adverse effects and inadequate solubility, necessitating the development of enhanced cutaneous delivery systems.

Objectives:

The objective of this study was to create and optimize a microemulgel for ibuprofen to improve solubility, permeability and prolonged release.

Methods:

Microemulsions were prepared using phase titration utilizing Tween 80, butanol and vegetable oil, thereafter incorporating carbopol gel. Preformulation studies encompassed solubility and partition coefficient. Post-formulation characterization involved globule size, zeta potential, pH, drug content and in-vitro/ex-vivo release analyses. Compatibility was evaluated by utilizing FTIR and DSC techniques.

Results:

The improved formulation (F3) exhibited a droplet size of 117.5 nm, a zeta potential of -6.47 mV and a drug content of 82.94%. FTIR and DSC analyses validated compatibility. Ex-vivo investigations revealed improved skin permeability and drug release conformed to the Korsmeyer-Pappas model (n = 0.626), signifying non-Fickian diffusion.

Conclusion:

The formulated ibuprofen microemulgel demonstrated stability, compatibility with skin and prolonged drug release, indicating its potential as an effective option for topical NSAID administration.

キーワード:

徐放性イブプロフェンマイクロエマルゲル不飽和三元相図皮膚透過経皮薬物送達システム

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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

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