骨肉腫幹細胞モデルにおけるMMP10の高発現と予後不良の予測
Makoto Yoshimoto1, Shohei Tsuji1, Soji Hayashida1
1Department of Bioactive Molecules, Pharmacology, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Gene
|February 1, 2026
まとめ
マトリックスメタロプロテアーゼ10(MMP10)は、骨肉腫幹細胞(OSC)で高発現しており、予後不良と関連しています。MMP10を阻害すると、腫瘍の増殖と幹細胞性が低下するため、骨肉腫の治療標的として示唆されます。
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