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関連する概念動画

Variation: Normal Distribution, Range, and Standard Deviation02:32

Variation: Normal Distribution, Range, and Standard Deviation

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In the field of psychology, there are several ways to organize measurements of a trait, feature, or characteristic (i.e., variables). Qualitative data, such as ethnicity, can be tabulated into a frequency count to provide information about the proportion, as well as the variety of groups in a sample or population. On the other hand, researchers can perform a wider set of calculations on quantitative data. The mean, mode, and median, for instance, are central tendency measures to identify a...
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Indicators02:39

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Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
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Confirmation Biases01:31

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The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
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Range00:59

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The range is one of the measures of variation. It can be defined as the difference between a dataset's highest and lowest values. For example, in the study of seven 16-ounce soda cans, the filled volume of soda was measured, thus producing the following amount (in ounces) of soda:
15.9; 16.1; 15.2; 14.8; 15.8; 15.9; 16.0; 15.5
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Normal Distribution01:11

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The normal, a continuous distribution, is the most important of all the distributions. Its graph is a bell-shaped symmetrical curve, which is observed in almost all disciplines. Some of these include psychology, business, economics, the sciences, nursing, and, of course, mathematics. Some instructors may use the normal distribution to help determine students’ grades. Most IQ scores are normally distributed. Often real-estate prices fit a normal distribution. The normal distribution is...
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Normal Stress01:19

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Normal stress is a type of stress that occurs when forces act perpendicular, or normal, to a material's cross-sectional area. This stress often arises in structures when subjected to axial loading, which is the application of force along the axis of an object. A practical example of this can be found in bridge truss members.
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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メブロフェニン肝機能指標の正常範囲の確認

Kathy P Willowson1,2, Geoff Schembri1, Elizabeth A Bailey1

  • 1Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia.

Asia Oceania journal of nuclear medicine & biology
|February 2, 2026
PubMed
まとめ
この要約は機械生成です。

本研究では、テクネチウム-99mメブロフェニン肝胆道シンチグラフィー（HBS）肝機能指標の正常範囲を確立する。体表面積で正規化されたメブロフェニン肝取り込み率（MURBSA）は約8.0±1.5%/分/m²であり、正常下限値は5.1%/分/m²である。

キーワード:
肝胆道シンチグラフィー肝臓メブロフェニン門脈塞栓術ラジオセラピー

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科学分野:

  • 核医学
  • 診断画像
  • 肝胆道系

背景:

  • テクネチウム-99mメブロフェニンを用いた肝胆道シンチグラフィー（HBS）は、肝機能を評価する上で重要である。
  • 信頼性の高い正常範囲の確立と測定不確実性の理解は、正確な臨床解釈に不可欠である。

研究 の 目的:

  • 肝機能の[99mTc] Tc-メブロフェニンHBS指標の正常範囲を定義する。
  • HBSにおける領域配置に関連する臨床測定値の不確実性を定量化する。
  • 肝機能指標と患者年齢との相関を調査する。

主な方法:

  • 肝疾患のない47人の患者が[99mTc] Tc-メブロフェニンを用いた動態HBSを受けた。
  • 血中クリアランス率、血中半減期、メブロフェニン肝取り込み率（MUR）、および体表面積で正規化されたMUR（MURBSA）を計算した。
  • ユーザー内変動と不確実性を繰り返し測定によって評価した。

主要な成果:

  • コホートの平均MURBSAは8.0±1.5%/分/m²であり、正常下限値は5.1%/分/m²と設定された。
  • 肝機能指標と患者年齢との間には有意な相関は見られなかった。
  • MURBSAの臨床測定値には±0.6%/分/m²の不確実性があることがわかった。

結論:

  • MURBSAの正常範囲は約8.0±1.5%/分/m²であり、正常下限値は5.1%/分/m²である。
  • 確立された正常範囲を下回るMURBSA値は、肝切除または肝治療を受ける患者において、より高いリスクを示す可能性がある。
  • 正確なHBS指標範囲は、肝疾患管理におけるリスク層別化に不可欠である。