Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Electron Affinity03:07

Electron Affinity

43.3K
The electron affinity (EA) is the energy change for adding an electron to a gaseous atom to form an anion (negative ion).
43.3K
Affinity and Avidity01:41

Affinity and Avidity

39.0K
Overview
39.0K
Affinity Chromatography01:03

Affinity Chromatography

3.0K
Affinity chromatography is a powerful technique extensively utilized for separating and purifying specific biomolecules from complex mixtures. It capitalizes on the highly selective binding between an analyte and its counterpart, such as antibody-antigen interactions. The counterpart is immobilized on the stationary phase, forming an affinity column. The stationary phase typically consists of solid support, such as agarose or porous glass beads, immobilizing the affinity ligand. The mobile...
3.0K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

8.7K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.7K
Enzyme Kinetics01:19

Enzyme Kinetics

104.1K
Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
104.1K
Primary Active Transport01:47

Primary Active Transport

198.5K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
198.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Mapping the avoid-ome: a systematic open-science approach to predictive ADMET.

Nature communications·2026
Same author

Modulating biomolecular condensates: a novel approach to drug discovery.

Nature reviews. Drug discovery·2022
Same author

Assessing the impact of generative AI on medicinal chemistry.

Nature biotechnology·2020
Same author

What Makes a Great Medicinal Chemist? A Personal Perspective.

Journal of medicinal chemistry·2018
Same journal

Library Docking for Cannabinoid-2 Receptor Ligands.

Journal of medicinal chemistry·2026
Same journal

Charting New Territory: Systematic Evaluation of the Drug Potential of <i>N</i>-Trifluoromethyl Amides, Ureas & Carbamates.

Journal of medicinal chemistry·2026
Same journal

Red-Light-Triggered <i>In Vitro</i> and <i>In Vivo</i> Photocatalytic Cancer Therapy with Polypyridyl Os(II) Photocatalysts.

Journal of medicinal chemistry·2026
Same journal

Novel Selenium-Containing Small Molecule PD-L1 Inhibitors: Design, Synthesis, and Evaluation of the Antitumor Activity.

Journal of medicinal chemistry·2026
Same journal

HsClpP-Engaging Selective Mitochondrial Pan-PDK Degraders for Cancer Therapy.

Journal of medicinal chemistry·2026
Same journal

Rational Development of Activatable Prodrugs of the GSTP1 Inhibitor NBDHEX: Turn-On NIR Fluorogenic Drug Delivery with Selective Anticancer Activity.

Journal of medicinal chemistry·2026
関連記事をすべて見る

関連する実験動画

Updated: Feb 4, 2026

Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells
11:30

Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells

Published on: January 26, 2017

15.6K

親和性の利点

Mark A Murcko1

  • 1Disruptive Biomedical, LLC, Holliston, Massachusetts 01746, United States.

Journal of medicinal chemistry
|February 2, 2026
PubMed
まとめ
この要約は機械生成です。

受容体への結合親和性の最適化は、単に最大化するだけでなく、創薬を加速します。親和性に焦点を当てることは、新しい医薬品の開発における効力、選択性、および速度を向上させる7つの主要な利点を提供します。

キーワード:
創薬結合親和性効力選択性医薬品開発

さらに関連する動画

Protein Complex Affinity Capture from Cryomilled Mammalian Cells
10:37

Protein Complex Affinity Capture from Cryomilled Mammalian Cells

Published on: December 9, 2016

15.6K
Author Spotlight: Affinity Purification of a Fibrinolytic Enzyme from Sipunculus nudus
06:45

Author Spotlight: Affinity Purification of a Fibrinolytic Enzyme from Sipunculus nudus

Published on: June 2, 2023

2.8K

関連する実験動画

Last Updated: Feb 4, 2026

Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells
11:30

Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells

Published on: January 26, 2017

15.6K
Protein Complex Affinity Capture from Cryomilled Mammalian Cells
10:37

Protein Complex Affinity Capture from Cryomilled Mammalian Cells

Published on: December 9, 2016

15.6K
Author Spotlight: Affinity Purification of a Fibrinolytic Enzyme from Sipunculus nudus
06:45

Author Spotlight: Affinity Purification of a Fibrinolytic Enzyme from Sipunculus nudus

Published on: June 2, 2023

2.8K

科学分野:

  • 医薬品化学
  • 創薬と開発
  • 薬理学

背景:

  • 創薬は多面的な最適化の課題です。
  • 現在の戦略では、薬物受容体相互作用の最適化の可能性を十分に活用していない可能性があります。
  • 結合親和性は、重要でありながら、しばしば過小評価されているパラメータです。

研究 の 目的:

  • 創薬における結合親和性の最適化への関心の高まりを提唱すること。
  • 戦略的な親和性最適化の大きな利点を強調すること。
  • 親和性最適化を実施するための実践的なガイダンスを提供すること。

主な方法:

  • この研究は、利点の列挙によって裏付けられた概念的な議論を提示します。
  • 単純な最大化ではなく、親和性最適化への戦略的なアプローチを強調しています。
  • プロジェクトチームに実践的な提案が提供されます。

主要な成果:

  • 結合親和性の最適化は、強力なツール化合物の発見を加速します。
  • 化合物の効力、選択性、および候補化合物の最適化をスピードアップします。
  • このアプローチは、多様な化学構造の探索を奨励し、ADME/Toxに影響を与えるオフターゲット効果を最小限に抑えます。

結論:

  • 結合親和性は、創薬パイプライン全体を通じて重要な戦略的要素です。
  • 親和性の最適化に焦点を当てたアプローチは、効率と成功率において大きな利点をもたらします。
  • 実践的な親和性最適化戦略を実施することで、より安全で効果的な医薬品の開発を加速できます。