甲状腺ホルモン代謝物であるトリアックは、幼若ゼブラフィッシュの骨石灰化を刺激する
Quinte F Geessinck1, Tiffany R Ernst1, Diana W M Hofman1
1Department of Plant & Animal Biology, Radboud Institute for Biological and Environmental Sciences, Radboud University, Nijmegen, the Netherlands.
The Journal of endocrinology
|February 2, 2026
まとめ
トリアック(3,3
背景:
- トリアック(3,3',5-トリヨードチロ酢酸)は、甲状腺様作用を持つ甲状腺ホルモン代謝物である。;甲状腺ホルモンは、骨格発生とカルシウム恒常性において重要な役割を果たしている。;環境汚染物質は、内分泌かく乱シグナル伝達経路をかく乱する可能性がある。
結論:
- トリアックは、カルシウム取り込みと内部カルシウム交換を調節することにより、骨石灰化に影響を与える。;トリアックは、下水流出物中に存在し、強力な生物学的効果を持つため、環境内分泌かく乱物質として作用する可能性がある。;トリアックの骨に対する直接的および間接的な作用機序を解明するためには、さらなる研究が必要である。
関連する概念動画
Functions of Thyroid Hormones
5.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.6K
Synthesis and Regulation of Thyroid Hormones
7.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.8K
Hormones and Bone Tissue
3.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.8K
Types of Hormones
83.6K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.6K
Types of Hormones
7.1K
Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
7.1K
Hormonal Regulation
48.1K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.1K


