フレイル高齢外来患者における心血管死亡予測のためのSCORE2-OPの外部検証
Charlotte M Nijskens1, Julia H I Wiersinga2, Janet L MacNeil-Vroomen1
1Department of Internal Medicine, Geriatrics Section, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health, Amsterdam, the Netherlands.
Journal of the American Medical Directors Association
|February 2, 2026
まとめ
SCORE2-OPツールは、アテローム性動脈硬化性心血管疾患(ASCVD)の既往歴のないフレイル高齢外来患者における心血管疾患(CVD)リスクの推定に有望です。この脆弱な集団におけるより広範な適用には、さらなる検証が必要です。
科学分野:
- 老年医学; 心血管医学;Epidemiology
背景:
- 正確な心血管疾患(CVD)リスク評価は、フレイル高齢者にとって、介入の有益性と有害性のバランスをとる上で重要です。
研究 の 目的:
- フレイル高齢外来患者におけるCVD死亡率の推定におけるSCORE2-OPリスク予測ツールのパフォーマンスを評価すること。
主な方法:
- アムステルダム・エイジング・コホート(n=1797)を用いた外部検証研究を実施しました。
主要な成果:
- 研究には1797人のフレイル高齢外来患者(中央年齢79歳)が含まれていました。
- 5年間の観察されたCVD死亡率は6.4%で、計算されたSCORE2-OPリスクの中央値は7.9%でした。
- SCORE2-OPは、中程度の識別能(全体でC指数0.59、ASCVDの既往歴のない患者で0.67)を示しました。
結論:
- SCORE2-OPは、ASCVDの既往歴のないフレイル高齢外来患者におけるCVD死亡率に対して、注目すべき識別能を示しました。
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