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Updated: Feb 4, 2026

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses

Published on: January 15, 2020

フェレットにおけるA(H5N1)インフルエンザのリスク評価の進展：空気感染ウイルスの排出パターンの比較評価

Joanna A Pulit-Penaloza¹, Troy J Kieran², Nicole Brock²

¹Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA. xzy5@cdc.gov.

Nature communications

|February 2, 2026

Abstract:

Recent A(H5N1) zoonotic cases linked to poultry and cattle in North America highlight the urgent need to assess the pandemic potential of emerging strains. Using male ferrets, we evaluate two B3.13 and two D1.1 genotype A(H5N1) viruses isolated from humans and observe fatal disease and varying capacities for direct contact transmission. To enhance pandemic risk assessment, we conduct aerosol sampling using cyclone BC251 and water condensation capture-based SPOT samplers and perform comparative analyses to include additional A(H5N1), A(H9N2), A(H7N9), and A(H1N1)pdm09 strains with known transmissibility profiles. Although none of the A(H5N1) strains transmit via the air, B3.13 viruses are detected at significantly higher levels compared to D1.1 strains. Here we show strong correlations between viral loads in nasal washes, airborne virus shedding, and transmissibility in ferrets, highlighting the value of these metrics for identifying zoonotic influenza viruses that may be adapting toward increased transmission potential.

キーワード:

A(H5N1)インフルエンザフェレットモデル空気感染ウイルス排出リスク評価人獣共通感染症パンデミック潜在性

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