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Updated: Feb 4, 2026

Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer

Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer

Published on: July 25, 2025

右側および左側結腸癌における間膜切除後の腫瘍学的転帰の比較

M Yılmaz¹, C Özcan², S Benli¹

¹Department of General Surgery/Surgical Oncology, Mersin University Faculty of Medicine, Mersin, Turkey.

Nigerian journal of clinical practice

|February 3, 2026

要旨

Context:

Colorectal cancer represents the third leading cause of cancer-related mortality worldwide. Emerging evidence suggests distinct biological differences between right-sided colon cancer (RCC) and left-sided colon cancer (LCC), although their prognostic significance remains controversial.

Aims:

To compare clinicopathological features and oncological outcomes between RCC and LCC following mesocolic resection and to identify independent prognostic factors.

Setting And Design:

A retrospective cohort study was conducted at a tertiary center between January 2010 and December 2020.

Methods And Materials:

A total of 948 patients with colon adenocarcinoma underwent curative resection and were categorized as RCC (n = 335) or LCC (n = 613), with analysis of demographic, pathological, and survival data focusing on overall survival and disease-free survival endpoints.

Statistical Analysis Used:

Continuous variables were compared using t-test or Mann-Whitney U test. Categorical variables were analyzed using Chi-square or Fisher's exact test. Univariate and multivariate Cox regression was performed to identify prognostic factors.

Results:

RCC patients were older (62.6 ± 14.8 vs 59.3 ± 14.4 years, P < 0.001) and more frequently female (48.1% vs 37.0%, P < 0.001). RCC tumors showed more aggressive characteristics: poor differentiation (15.8% vs 7.7%), advanced T-stage (97.6% vs 83.9%), and higher KRAS mutations (53.4% vs 37.4%) (all P < 0.001). At median follow-up of 78.4 months, RCC demonstrated inferior survival with OS 79.1% vs 85.0% (P = 0.031) and DFS 74.0% vs 78.0% (P = 0.042). Multivariate analysis confirmed right-sided location as an independent adverse prognostic factor (Hazard Ratio = 1.45, 95% Confidence Interval: 1.05-2.01, P = 0.024).

Conclusions:

RCC showed more aggressive features and worse survival than LCC, suggesting tumor sidedness as an independent prognostic factor.

キーワード:

結腸腫瘍大腸癌の側性原発腫瘍部位予後予測バイオマーカー生存分析

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