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Updated: Feb 4, 2026

Discovering Middle Ear Anatomy by Transcanal Endoscopic Ear Surgery: A Dissection Manual

Discovering Middle Ear Anatomy by Transcanal Endoscopic Ear Surgery: A Dissection Manual

Published on: January 11, 2018

CRSwNP患者におけるメポリズマブの中耳疾患および聴覚転帰への影響

Anne-Sophie Homøe¹, Jens Tidemandsen², Kasper Aanæs¹

¹Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

The Laryngoscope

|February 3, 2026

要旨

Objective:

Otitis media with effusion (OME) is frequently observed in patients with severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)-yet it remains underrecognized. Both conditions are debilitating and may share type 2 inflammatory mechanisms. This study investigates the prevalence of OME (measured by tympanometry) in patients with CRSwNP and evaluates the effect of biologic treatment with mepolizumab, with or without combined FESS, on hearing outcomes as well as otologic symptoms.

Methods:

Secondary analysis of a randomized controlled trial (RCT) (n = 58) comparing FESS and mepolizumab versus mepolizumab alone in patients suffering from severe CRSwNP. Tympanometry, audiometry, and patient-reported outcomes (SNOT-22 and COMOT-15) were assessed at baseline and after 6 months.

Results:

At baseline, 22.8% (13/57) of patients had pathological tympanometry (OME), consistent with previous prevalence estimates. After 6 months, the proportion decreased to 14% (p = 0.07). No significant changes were observed in pure tone averages (PTA). In contrast, self-reported outcomes improved significantly, with reductions in both COMOT-15 and SNOT-22 scores (p < 0.05), independent of baseline tympanometry status.

Conclusion:

Mepolizumab treatment was associated with a trend toward reduced middle ear symptoms and significant improvement in self-reported otologic symptoms, supporting the concept of global type 2 airway inflammation and the clinical relevance of assessing ear disease in CRSwNP.

キーワード:

CRSwNP 滲出性中耳炎生物学的製剤メポリズマブ中耳疾患中耳症状モノクローナル抗体

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Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

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