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Updated: Feb 5, 2026

Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure

Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure

Published on: September 4, 2010

小型高圧質量分析計を用いたVOC検出用大気圧光イオン化源の開発

Alan M Rowland¹, Stephen E Smith¹, Ella F Vandergriff¹

¹Furman University, Greenville, South Carolina, USA.

Rapid communications in mass spectrometry : RCM

|February 3, 2026

Abstract:

With the goal of sensitive, selective, targeted, and portable VOC quantification, an atmospheric pressure photoionization (APPI) source was developed for a miniature high pressure mass spectrometer, the MX908. The APPI source consists of a VUV lamp that was encased in a custom 3D-printed apparatus. Using m-xylene as the testing standard, the effects of pressure, axial RF voltage, aperture voltage, and humidity on the instrument were investigated and optimized. Operating at 0.8 Torr with ambient air as the buffer gas, the instrument showed linearity from 25 to 500 ppbV for benzene, toluene, ethylbenzene, and m-xylene without preconcentration.

キーワード:

大気圧光イオン化揮発性有機化合物質量分析計ポータブル分析環境モニタリング

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Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

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Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry

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