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Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Protein-Protein Interfaces

Protein-Protein Interfaces

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.

Tissues

Tissues

Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.

Tissues

Tissues

Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...

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Updated: Feb 5, 2026

Subdural Soft Electrocorticography ECoG Array Implantation and Long-Term Cortical Recording in Minipigs

Subdural Soft Electrocorticography ECoG Array Implantation and Long-Term Cortical Recording in Minipigs

Published on: March 31, 2023

生体インターフェース用ソフト・フレキシブル・伸縮性プラットフォーム

Kento Yamagishi¹, Sunghoon Lee^1,2,3, Tomoyuki Yokota^1,4

¹Department of Electrical Electronic Engineering and Information Systems, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|February 3, 2026

まとめ

この要約は機械生成です。

本レビューは、組織とのシームレスな統合のためのソフトで柔軟、伸縮性のあるエレクトロニクスを明確にする。様々な臓器のための生体電子デバイスの設計原則と進歩を概説し、ヘルスケア技術を向上させる。

キーワード:

生体統合エレクトロニクスフレキシブルエレクトロニクス伸縮性エレクトロニクス組織接着剤

さらに関連する動画

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing

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A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

Published on: January 21, 2016

関連する実験動画

Last Updated: Feb 5, 2026

Subdural Soft Electrocorticography ECoG Array Implantation and Long-Term Cortical Recording in Minipigs

Subdural Soft Electrocorticography ECoG Array Implantation and Long-Term Cortical Recording in Minipigs

Published on: March 31, 2023

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing

Published on: March 17, 2023

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires

Published on: January 21, 2016

科学分野:

生体エレクトロニクス
材料科学
生体医工学

背景:

エレクトロニクスと生体組織とのシームレスな統合には、機械的特性の一致が必要である。
ソフト、フレキシブル、伸縮性エレクトロニクスを区別することは、デバイス設計にとって重要である。
不均一な臓器は、生体電子インターフェースに特有の機械的課題をもたらす。

研究の目的:

「ソフト」、「フレキシブル」、「伸縮性」エレクトロニクスの定義を明確にする。
生体電子デバイスを設計するための組織力学フレームワークを確立する。
組織インターフェース生体エレクトロニクスの最近の進歩をレビューし、設計原則を概説する。

主な方法:

電子材料の特性を組織力学フレームワークにリンクさせる。
最近の進歩を組織標的プラットフォームに整理する。
液金や生分解性エレクトロニクスなどの新しい材料システムを強調する。

主要な成果:

主要な機械的設計原理を特定した：超薄型構造、伸縮性アーキテクチャ、生体接着インターフェース。
皮膚、神経、心臓、消化器系アプリケーションのための組織標的プラットフォームを実証した。
機械的適応性を拡張し、一時的なエレクトロニクスを可能にする高度な材料を導入した。

結論:

ソフトな組織インターフェース生体エレクトロニクスは、ヘルスケアのための多用途なツールボックスを提供する。
弾性率、接着、ひずみ許容に関する設計規則の統一が不可欠である。
生体エレクトロニクスは、将来の医療技術のために、ウェアラブル、インプラント可能、一時的な形式を橋渡しすることができる。