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トランスアミン酸ボーラスと点滴注入は逆説的に補体活性を増加させる：PATCH試験の二次研究

Nicolle Barmettler1, Elizabeth R Maginot, Ernest E Moore

  • 1From the Division of Acute Care Surgery, Department of Surgery (N.B., E.R.M., F.I.G., C.M.W., T.B.M., A.C., K.S.S., D.H., G.E.V., R.H., C.D.B.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Surgery (E.E.M., J.G.C.), Ernest E Moore Shock Trauma Center, Denver Health; Department of Surgery (H.B.M.), AdventHealth Porter, Denver, Colorado; Department of Cardiology (D.F.D.), Bern Center for Precision Medicine, University Hospital of Bern, Bern, Switzerland; School of Medicine and Psychology (R.G.), Australian National University, Canberra, Australia; Department of Biological Sciences, Hunter College (I.M.B.), New York, New York; The Australian Centre for Blood Diseases (R.L.M.), Monash University; Emergency and Trauma Centre (B.M.), Alfred Health, Melbourne, Australia; Department of Surgery (M.A.S.), Uniformed Services University of Health Sciences, Bethesda, Maryland; Section of Trauma and Acute Care Surgery, Department of Surgery (S.E.R.), University of Chicago Pritzker School of Medicine, Chicago, Illinois; Sauaia Statistical Solutions, L.L.C. (A.S.), Denver, Colorado; and Department of Cellular and Integrative Physiology (C.D.B.), University of Nebraska Medical Center, Omaha, Nebraska.

The journal of trauma and acute care surgery
|February 3, 2026
PubMed
まとめ

トランスアミン酸（TXA）は、外傷患者における早期の補体活性を低下させなかった。逆説的に、TXAは24時間で補体活性を増加させ、炎症反応における複雑な役割と最適な投与戦略の必要性を示唆している。

キーワード:
トランスアミン酸補体活性線溶亢進

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