Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Secondary Active Transport01:55

Secondary Active Transport

137.9K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
137.9K
Secondary Active Transport01:32

Secondary Active Transport

9.6K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
9.6K
Complement System01:27

Complement System

10.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.7K
Complementation Tests00:49

Complementation Tests

6.3K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.3K
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

60.5K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.5K
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Traumatic hemothorax activates complement, stimulates proinflammatory cytokine release, and primes neutrophils for local inflammatory reactive oxygen species production.

The journal of trauma and acute care surgery·2026
Same author

Efficacy of Short Course Cognitive Behavioral Therapy on Stress Reduction Among First-Year Surgical Residents.

Journal of surgical education·2026
Same author

Platelet storage lesion underlies changes in plasminogen activator inhibitor-1 activity in stored whole blood.

The journal of trauma and acute care surgery·2026
Same author

Whole blood storage time impairs clot strength with minimal change in functional fibrinogen concentration.

Transfusion·2026
Same author

Is early venous thromboembolism prophylaxis safe and effective in trauma patients requiring urgent neurosurgical interventions: analysis of the prospective multicenter CLOTT study.

Trauma surgery & acute care open·2026
Same author

Thrombelastography-estimated functional fibrinogen in healthy volunteers, end-stage renal disease, and trauma: inaccurate when most needed.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Response to a Letter to the Editor "interpreting prophylactic antibiotic use in closed basilar skull fractures: Caution in claims-based evidence".

The journal of trauma and acute care surgery·2026
Same journal

The impact of fathers and male role models on recovery and resilience in pediatric victims of violent trauma.

The journal of trauma and acute care surgery·2026
Same journal

Peptidyl arginine deiminase 2 (PAD2) inhibition is associated with acute and long-term benefits in a murine model of traumatic brain injury.

The journal of trauma and acute care surgery·2026
Same journal

CT-first resuscitation for severe blunt trauma: A propensity score-matched cohort study.

The journal of trauma and acute care surgery·2026
Same journal

The intravenous targeted nanopeptide, CAQK, is neuroprotective and improves motor function after spinal cord injury in rats.

The journal of trauma and acute care surgery·2026
Same journal

Authors' reply to the Letter to the Editor on "Use of extracorporeal membrane oxygenation in traumatic injuries with acute respiratory distress syndrome: A systematic review and meta-analysis".

The journal of trauma and acute care surgery·2026
関連記事をすべて見る

関連する実験動画

Updated: Feb 5, 2026

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.6K

トランスアミン酸ボーラスと点滴注入は逆説的に補体活性を増加させる：PATCH試験の二次研究

Nicolle Barmettler1, Elizabeth R Maginot, Ernest E Moore

  • 1From the Division of Acute Care Surgery, Department of Surgery (N.B., E.R.M., F.I.G., C.M.W., T.B.M., A.C., K.S.S., D.H., G.E.V., R.H., C.D.B.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Surgery (E.E.M., J.G.C.), Ernest E Moore Shock Trauma Center, Denver Health; Department of Surgery (H.B.M.), AdventHealth Porter, Denver, Colorado; Department of Cardiology (D.F.D.), Bern Center for Precision Medicine, University Hospital of Bern, Bern, Switzerland; School of Medicine and Psychology (R.G.), Australian National University, Canberra, Australia; Department of Biological Sciences, Hunter College (I.M.B.), New York, New York; The Australian Centre for Blood Diseases (R.L.M.), Monash University; Emergency and Trauma Centre (B.M.), Alfred Health, Melbourne, Australia; Department of Surgery (M.A.S.), Uniformed Services University of Health Sciences, Bethesda, Maryland; Section of Trauma and Acute Care Surgery, Department of Surgery (S.E.R.), University of Chicago Pritzker School of Medicine, Chicago, Illinois; Sauaia Statistical Solutions, L.L.C. (A.S.), Denver, Colorado; and Department of Cellular and Integrative Physiology (C.D.B.), University of Nebraska Medical Center, Omaha, Nebraska.

The journal of trauma and acute care surgery
|February 3, 2026
PubMed
まとめ
この要約は機械生成です。

トランスアミン酸（TXA）は、外傷患者における早期の補体活性を低下させなかった。逆説的に、TXAは24時間で補体活性を増加させ、炎症反応における複雑な役割と最適な投与戦略の必要性を示唆している。

キーワード:
トランスアミン酸補体活性線溶亢進

さらに関連する動画

Author Spotlight: Developing a Safer and More Efficient Treatment Protocol for Wasting Marmoset Syndrome (WMS)
03:07

Author Spotlight: Developing a Safer and More Efficient Treatment Protocol for Wasting Marmoset Syndrome (WMS)

Published on: July 12, 2024

1.6K
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

6.4K

関連する実験動画

Last Updated: Feb 5, 2026

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.6K
Author Spotlight: Developing a Safer and More Efficient Treatment Protocol for Wasting Marmoset Syndrome (WMS)
03:07

Author Spotlight: Developing a Safer and More Efficient Treatment Protocol for Wasting Marmoset Syndrome (WMS)

Published on: July 12, 2024

1.6K
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

6.4K

科学分野:

  • 外傷・救急医学
  • 免疫学
  • 薬理学

背景:

  • トランスアミン酸（TXA）は、多発外傷患者において生存率のわずかな改善を示しますが、その効果は止血作用を超えて及ぶ可能性があります。
  • プラスミンは補体タンパク質を活性化し、TXAはプラスミン生成を阻害します。
  • 本研究では、外傷患者における補体活性に対するTXAの影響を調査しました。

研究 の 目的:

  • TXA投与が多発外傷患者の補体活性を低下させるかどうかを判断すること。
  • 外傷後のTXA、プラスミン、および補体経路の関係を調査すること。

主な方法:

  • PATCH試験（TXA vs プラセボ）の多発外傷患者53名から採取した血漿サンプルを分析しました。
  • 補体活性マーカー（C3a、C5a、sC5b-9）およびプラスミン-アンチプラスミンレベルをED、8時間、24時間で測定しました。
  • TXA群とプラセボ群の間で統計的比較を行いました。

主要な成果:

  • 早期（ED、8時間）の時点では、TXA群とプラセボ群の間で補体活性またはプラスミン-アンチプラスミンレベルに有意な差はありませんでした。
  • TXA群では、入院24時間後にC3aおよびC5aレベルの有意な増加が観察されました。
  • これらの所見は、TXAが外傷後のより遅い時期に補体活性を逆説的に増強する可能性を示唆しています。

結論:

  • 多発外傷患者において、TXAの投与は24時間で補体活性を逆説的に増加させました。
  • これらの結果は、TXAが外傷後の炎症経路に関与していることを示しています。
  • 遅発性の炎症効果のため、外傷における最適なTXA投与戦略についてはさらなる調査が必要です。