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Updated: Feb 5, 2026

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

組換え型および生弱毒型帯状疱疹ワクチンの誘導するFc媒介性免疫エフェクター機能

Zhuangzhuang Huang¹, Pengfei Jin², Hongxing Pan^1,2

¹School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, China.

Expert review of vaccines

|February 4, 2026

要旨

Background:

The role of Fc-mediated immune responses in protecting against herpes zoster remains poorly understood. This study aimed to evaluate the Fc-mediated immune responses of anti-VZV glycoprotein E antibodies induced by two licensed varicella-zoster virus vaccine.

Research Design And Methods:

We established two cohorts, each consisting of 48 healthy participants aged 50 or above, who received either the ZVL or RZV. Serum samples were measured to evaluate the Fc-mediated immune responses for antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and antibody-dependent neutrophil phagocytosis (ADNP) against VZV-gE. The correlations between Fc-mediated functions and the IgG levels were also analyzed.

Results:

Both ZVL and RZV significantly induced Fc effector function responses against HZ in participants after vaccination. Compared with ZVL recipients, RZV recipients exhibited significantly higher increase-fold of ADCC responses (ZVL: 1.93-fold; RZV: 8.44-fold, p < 0.001). In each vaccine group, the younger recipients showed higher ADCC responses than did the older (ZVL: 2.17-fold vs. 1.45-fold, p = 0.0136; RZV: 8.93-fold vs. 7.43-fold, p = 0.0677). Similar patterns were observed for ADCP and ADNP responses.

Conclusion:

RZV induced superior Fc effector functions of VZV-gE antibodies compared to ZVL did. Older adults exhibited weaker Fc-mediated responses compared to younger adults following vaccination.

キーワード:

ADCC ADCP ADNP Fcエフェクター機能帯状疱疹ワクチン

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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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