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Updated: Feb 5, 2026

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アナキンラ抵抗性のシュニッツラー症候群に対するカナキヌマブの効果的な治療法：症例に基づくレビュー

Sergio De Santos Belinchón¹, Cristina Ausín García^1,2, Pablo Daniel Lorenzo Barcia³

¹Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Internal medicine journal

|February 4, 2026

Abstract:

Schnitzler syndrome is a rare autoinflammatory syndrome caused by a dysregulation of the interleukin-1β signalling pathway. Symptoms tend to appear in middle age and include urticariform skin lesions, fever, bone pain, lymphadenopathy and IgM monoclonal gammopathy. Interleukin-1 (IL-1) targeted therapy constitutes the basis for treatment and can lead to complete resolution of symptoms. We report a case of Schnitzler syndrome in a 49-year-old man refractory to anakinra and subsequently treated successfully with canakinumab.

キーワード:

シュニッツラー症候群アナキンラカナキヌマブ単クローン性ガンモパチー蕁麻疹様皮疹

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