Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

The Evidence for Evolution02:55

The Evidence for Evolution

48.3K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.3K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

53.6K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.6K
Convergent Evolution01:54

Convergent Evolution

33.0K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
33.0K
Rab Cascades01:25

Rab Cascades

3.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
3.6K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

4.3K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
4.3K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Who Speaks for the Dead? Of Communities and Stewardship in Legacy Collections of Human Remains.

American journal of biological anthropology·2026
Same author

AABA Task Force on the Ethical Study of Human Remains Recommendations: Proposal for the Management and Oversight of Community Partnership and Ethical Stewardship of Human Remains.

American journal of biological anthropology·2026
Same author

Evolving a Field: Can Evolutionary Theory Provide What the Study of Human Evolution Requires?

American journal of biological anthropology·2026
Same author

Cochlea development shapes bat sensory system evolution.

Anatomical record (Hoboken, N.J. : 2007)·2023
Same author

Variation in human limb joint articular morphology.

American journal of biological anthropology·2023
Same author

Variation in ontogenetic trajectories of limb dimensions in humans is attributable to both climatic effects and neutral evolution.

Journal of human evolution·2023

関連する実験動画

Updated: Feb 6, 2026

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
07:27

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance

Published on: August 25, 2021

2.3K

節分組織における阻害カスケードモデルと進化

Benjamin M Auerbach1, Charles C Roseman2

  • 1The University of Tennessee, Department of Ecology & Evolutionary Biology, Knoxville, TN 37996, United States.

Evolution; international journal of organic evolution
|February 4, 2026
PubMed
まとめ

発生と進化の阻害カスケードモデル（ICM）には欠陥がある。我々の再定式化は、その明白な成功が生物学的現実ではなく、統計的スケーリングの偽像であることを示している。

科学分野:

  • 発生生物学
  • 進化学
  • 形態形成

背景:

  • 阻害カスケードモデル（ICM）は、発生と進化的変異を結びつける。
  • モルляр歯のような連続的な形質は、活性化プロセスと阻害プロセスによって制御されると提案している。
  • 以前の適用では、連続的および非連続的形質の両方で良好な適合性を示した。

研究 の 目的:

  • 阻害カスケードモデル（ICM）を批判的に再評価すること。
  • ICMの適合性が統計的標準化の偽像であるかどうかを調査すること。
  • ICMの妥当性を発生学的、変動的、進化的レベルで検証すること。

主な方法:

  • ICMの数学的および概念的基礎を再定式化した。
  • 再定式化したICMを生物学的、非生物学的、およびシミュレートされたデータに適用した。
  • モデルの適合性を評価するために、統計的手法を用いてデータを分析した。

主要な成果:

  • ICMの適合性の良さは、相関値のスケーリングの偽像であることを実証した。
  • ICMを支持する証拠は発生学的レベルでは見つからなかった。
  • ICMを変動的または進化的レベルで支持する証拠は見つからなかった。
キーワード:
進化発生生物学進化遺伝学阻害カスケード連続的成長

さらに関連する動画

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

10.1K
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.2K

関連する実験動画

Last Updated: Feb 6, 2026

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
07:27

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance

Published on: August 25, 2021

2.3K
Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

10.1K
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.2K

結論:

  • 阻害カスケードモデル（ICM）は、形態形成の有効な説明を提供しない。
  • モデルの認識された成功は、生物学的プロセスではなく、統計的手法の偽像である。
  • 発生、変異、または進化全体にわたるICMの経験的サポートはない。