小児患者における下垂体 incidentaloma の自然史：単一施設の後ろ向き解析

With increased use of advanced imaging techniques, pediatric pituitary incidentalomas are more frequently identified. There is limited data and sparse clinical practice guidelines about prognosis and management of pediatric patients with nonfunctioning pituitary abnormalities.

The aim of this study is to provide information about clinical features and clinical course of pediatric patients who had incidental pituitary lesion identified on MRI and to identify characteristics that may portend development of endocrinopathy or neurologic symptoms.

Retrospective observational study reviewing 24 years of patients.

Single-center, tertiary care academic children's hospital.

Pediatric patients with a pituitary incidentaloma identified on MRI with no predisposing factors to developing brain lesions.

Electronic health record was queried to identify patients with MRI imaging of brain and pituitary lesions who were evaluated by neurosurgery and/or endocrinology. Patient characteristics, clinical course, and serial imaging studies were reviewed for patients found to have pituitary incidentaloma.

Thirty-five patients with pituitary incidentalomas were identified. Twenty-five lesions were microincidentalomas (<10mm); four enlarged to become macroincidentalomas (≥10mm). Twenty-seven lesions were cystic. Headache (51%) was the most common reason for initial imaging. No patient developed an endocrinopathy or new neurological symptoms over a median follow up of 23 months.

Pediatric pituitary incidentalomas are generally benign. Patients did not develop endocrinopathies or neurological symptoms. In the absence of new symptoms, monitoring clinically rather than with recurrent imaging or lab evaluation may be warranted.