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Updated: Feb 6, 2026

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
Published on: March 6, 2009
説明可能な不均衡分類のためのクラス固有の反事実に対する適応的サンプル反発
Yu Hao1, Xin Gao1, Xinping Diao2
1School of Intelligent Engineering and Automation, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
Abstract:
Enhancing model classification capability for samples within overlapping regions in complex feature spaces remains a key challenge in imbalanced classification research. Existing mainstream methods at the data-level and algorithm-level primarily rely on original sample distribution information to reduce overlap impact, without deeply modeling the causal relationship between features and labels. Furthermore, these approaches often overlook instance-level explanations that could guide deep discriminative information mining for samples of different classes in overlapping regions, thus the improvement on classification performance and model credibility may be constrained. This paper proposes an explainable imbalanced classification framework with adaptive sample repulsion against class-specific counterfactuals (CSCF-SR), forming a closed-loop between explanation generation and classification decisions by dynamically regulating the feature-space distribution through generated counterfactual samples. Two core phases are jointly optimized. (1) Counterfactual searching: a class-specific dual-actor architecture based on reinforcement learning decouples perturbation policy learning for majority and minority classes. A multi-step dynamic perturbation mechanism is designed to control counterfactual search behavior more precisely and smoothly, effectively generating reliable counterfactual samples. (2) Adaptive sample repulsion against counterfactuals: exploiting the inter-class discriminative information in displacement vectors between counterfactual and original samples, each original sample is adaptively perturbed along the direction opposite to its counterfactual. This fine-grained regulation gradually displaces samples from the overlapping region and clarifies class boundaries. Experiments on 50 imbalanced datasets demonstrate that CSCF-SR has a performance advantage over 27 typical imbalanced classification methods on both F1-score and G-mean, with more pronounced improvements on 25 datasets with severe class overlap.
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