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関連する概念動画

Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
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System of Memory01:23

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Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
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Working Memory01:24

Working Memory

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Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
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Updated: Feb 6, 2026

Cross-Modal Multivariate Pattern Analysis
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統合失調症における視覚作動記憶障害の時空間的デコーディング：EEG多変量パターン解析を用いて

Zhongsi Wang1, Yang Jiaqin1, Yuyan Jing1

  • 1School of Psychology, Qufu Normal University, Qufu, 273165, China.

Psychiatry research. Neuroimaging
|February 4, 2026
PubMed
まとめ

統合失調症患者は、記憶課題中に健常者と比較して神経信号伝達と識別可能性の低下を特徴とする視覚作動記憶（vWM）の障害を示す。これらの所見は、vWM維持に重要な後頭部領域における脳活動の障害を強調している。

キーワード:
認知 deficitsデコーディング事象関連電位統合失調症視覚作動記憶

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科学分野:

  • 認知神経科学
  • 神経画像
  • 精神医学

背景:

  • 視覚作動記憶（vWM）障害は統合失調症の中核的特徴である。
  • これらのvWM障害の根底にある正確な神経メカニズムと時空間的ダイナミクスは完全には理解されていない。

研究 の 目的:

  • 統合失調症患者（PSZ）と健常対照群（HCS）におけるvWMの神経信号伝達の違いを調査すること。
  • 高度な神経画像技術を用いてvWM障害の時空間的ダイナミクスを特徴づけること。

主な方法:

  • 多変量パターン分類（MVPC）とサーチライト解析を脳波（EEG）データに適用した。
  • 様々な記憶負荷（1T/2T/4T）を用いた変化検出課題中の対側遅延活動（CDA）を解析した。
  • 時間的および空間的次元の両方で記憶負荷と側方情報をデコードした。

主要な成果:

  • 統合失調症患者は健常対照群と比較して有意に低いCDA振幅を示した。
  • MVPCは、遅延期間（176-656 ms）中にPSZで有意に低いデコーディング精度を明らかにし、パターン識別可能性の低下を示唆した。
  • サーチライト解析は、PSZにおける広範なデコーディング低下を示し、特に後頭頂葉領域で顕著であった。

結論:

  • 統合失調症は、vWM維持を支持する神経メカニズムにおける時空間的障害と関連している。
  • 神経識別可能性の低下と後頭部脳活動は、統合失調症におけるvWM障害の主な特徴である。
  • これらの所見は、統合失調症に対する神経マーカー誘導型認知介入の開発を導く可能性がある。