Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Acidity and Basicity of Alcohols and Phenols02:36

Acidity and Basicity of Alcohols and Phenols

22.2K
Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.
22.2K
Acidity and Basicity of Carboxylic Acid Derivatives01:25

Acidity and Basicity of Carboxylic Acid Derivatives

4.4K
Carboxylic acids are the strongest among organic acids, as they readily lose the hydroxyl proton to form a resonance-stabilized carboxylate ion. In comparison, the acid derivatives lack acidic hydrogens directly attached to a functional group. In these compounds, the acidic nature arises from their ability to lose α hydrogens, making them weakly acidic.
The relative acidic strength of the derivatives can be explained based on the extent of resonance stabilization of the conjugate base. The...
4.4K
Bile01:19

Bile

4.3K
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
4.3K
Energy Basics02:27

Energy Basics

47.7K
Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
47.7K
Drug Absorption: Factors Affecting GI Absorption01:19

Drug Absorption: Factors Affecting GI Absorption

6.3K
The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
6.3K
Amino acids03:42

Amino acids

105.7K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
105.7K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Mice with humanized FXR ligand-binding domain display distinct metabolic responses upon pharmacological FXR stimulation.

Journal of lipid research·2026
Same author

Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis.

Molecular metabolism·2026
Same author

Connecting fragmented aging research through the European Federation for Aging Research.

Nature aging·2026
Same author

Bile Acid Detergency as Determinant of Liver Pathology in a Humanized Mouse Model of Progressive Familial Intrahepatic Cholestasis Type 3.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism.

Molecular metabolism·2026

関連する実験動画

Updated: Feb 6, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.6K

基本的なこと：脂肪吸収における胆汁酸

Folkert Kuipers1, Henkjan J Verkade2, Jan Freark de Boer3

  • 1European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.

Cell metabolism
|February 4, 2026
PubMed
まとめ

体内の天然の石鹸である胆汁酸は、腸管での脂肪吸収に不可欠です。その機能は、胆汁酸と脂肪酸の構造間の複雑な相互作用に依存しており、全体的な代謝に影響を与えます。

キーワード:
胆汁酸脂肪吸収代謝

さらに関連する動画

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
09:21

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Published on: January 4, 2016

10.4K
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

10.0K

関連する実験動画

Last Updated: Feb 6, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.6K
Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
09:21

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Published on: January 4, 2016

10.4K
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

10.0K

科学分野:

  • 生化学; 代謝科学; 消化器病学

背景:

  • 胆汁酸は肝臓で合成される両親媒性分子であり、消化と代謝において重要な役割を果たしています。その古典的な機能は、腸管での食事性脂肪および脂溶性ビタミンの吸収を促進することです。このプロセスを制御する胆汁酸と脂肪酸の正確な構造的相互作用は、活発な調査分野であり続けています。

研究 の 目的:

  • 腸管脂肪吸収における胆汁酸プールサイズと組成の役割を調査すること。脂肪吸収中の胆汁酸と脂肪酸間の相互作用の構造的基盤を解明すること。胆汁酸-脂肪酸相互作用の調節のより広範な代謝への影響を理解すること。

主な方法:

  • 胆汁酸プールサイズと組成を正確に操作するために革新的なマウスモデルを利用しました。腸管環境における胆汁酸と脂肪酸の構造的特性を分析するために高度な技術を採用しました。これらの変更が腸管脂肪吸収効率に及ぼす影響を評価しました。

主要な成果:

  • 胆汁酸の脂肪吸収における古典的な機能は、胆汁酸と脂肪酸の構造間の特定の相互作用に критически 依存していることを実証しました。胆汁酸プールサイズと組成の変化が腸管脂肪吸収の効率に大きく影響することを示しました。胆汁酸と脂肪酸間の相互作用を媒介する重要な構造的特徴を特定しました。

結論:

  • 胆汁酸による腸管脂肪の吸収は、胆汁酸と脂肪酸の間の複雑な構造的関係によって支配される洗練されたプロセスです。胆汁酸の代謝と構造を調節することは、代謝性疾患の潜在的な治療標的を提供します。この研究は、脂質消化と吸収の基本的なメカニズムに関する新しい洞察を提供します。