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Updated: Feb 6, 2026

Microinjection Wound Assay and In vivo Localization of Epidermal Wound Response Reporters in Drosophila Embryos.

Microinjection Wound Assay and In vivo Localization of Epidermal Wound Response Reporters in Drosophila Embryos.

Published on: November 1, 2013

症例報告：HER2陽性乳癌2例における細胞内細胞報告を用いた術前化学療法の異なる反応の比較

Danhong Zhan¹, Zhikang Li¹, Kaiting Yu²

¹Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Frontiers in medicine

|February 5, 2026

Abstract:

Neoadjuvant chemotherapy (NACT) is commonly applied in human epidermal growth factor receptor 2 (HER2)-positive breast cancer to reduce tumor size and increase the likelihood of breast-conserving surgery. However, predictive markers of response remain limited. We report two cases of HER2-positive breast cancer with divergent responses to NACT, highlighting the dynamics of cell-in-cell structures (CICs). Both patients initially presented with palpable breast masses and biopsy-confirmed HER2-positive invasive carcinoma with frequent CICs. After NACT, one patient achieved a favorable pathological response, accompanied by a reduction in CICs frequency. In contrast, the other patient showed limited response, with persistent complex CICs, which led to an adjustment of the adjuvant regimen. These observations suggest that dynamic cell-in-cell (CIC) patterns may reflect heterogeneous tumor responses to NACT, providing insights for individualized treatment planning.

キーワード:

HER2 症例報告細胞内細胞構造術前化学療法多様性

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