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Updated: Feb 7, 2026

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

宿便の微生物叢：宿主微生物叢相互作用からの洞察

Khiem C Lam^1,2, Romina S Goldszmid¹

¹Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland.

Cancer discovery

|February 6, 2026

Abstract:

Gut microbiota has emerged as a determinant of cancer therapy efficacy, shaping immune responses both systemically and locally within the tumor microenvironment. In this piece, we discuss current insights into the mechanistic basis of these interactions, with a focus on type I interferon as a central mediator of microbiota-driven immune modulation.

キーワード:

腸内細菌がん免疫免疫調節腫瘍微小環境インターフェロン

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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

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